ArticleHuman genetics2013
Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy.
Article in Human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 39 citations in OpenAlex.
- Human Genetic Susceptibility of Leprosy Recurrence.Scientific reports · 2020Trial
- Bridging pleiotropic mechanisms in leprosy type-1 reactions and neurodegenerative diseases.Scientific reports · 2025Article
- Machine learning approaches to identify systemic lupus erythematosus in anti-nuclear antibody-positive patients using genomic data and electronic health records.BioData mining · 2024Article
- Investigation ofBiomedicines · 2023Article
- Review
- Genetics of leprosy: today and beyond.Human genetics · 2020Review
- Reply to Zhang et al.: The differential role of LRRK2 variants in nested leprosy phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.PLoS neglected tropical diseases · 2020Article
- TheScience signaling · 2020Article
- Genome-wide association study identifies loci associated with milk leukocyte phenotypes following experimental challenge with Streptococcus uberis.Immunogenetics · 2018Article
- Human genetics of mycobacterial disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Genetic Susceptibility to Leprosy-From Classic Immune-Related Candidate Genes to Hypothesis-Free, Whole Genome Approaches.Frontiers in immunology · 2018Review
- Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation.PLoS genetics · 2017Article
- Evaluating the Impact of LTA4H Genotype and Immune Status on Survival From Tuberculous Meningitis.The Journal of infectious diseases · 2017Article
- A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy.PLoS genetics · 2017Article
- Age-Dependent Association ofFrontiers in immunology · 2017Article
- Soil-transmitted helminth infections and leprosy: a cross-sectional study of the association between two major neglected tropical diseases in Indonesia.BMC infectious diseases · 2016Article
- Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases.PLoS neglected tropical diseases · 2016Review
- Human Genetic Ancestral Composition Correlates with the Origin of Mycobacterium leprae Strains in a Leprosy Endemic Population.PLoS neglected tropical diseases · 2015Article
- Gene Association with Leprosy: A Review of Published Data.Frontiers in immunology · 2015Review
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Authors and funding
13 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the persistent challenges of genetic association studies is the replication of genetic marker-disease associations across ethnic groups. Here, we conducted high-density association mapping of PARK2/PACRG SNPs with leprosy and identified 69 SNPs significantly associated with leprosy in 198 single-case Vietnamese leprosy families. A total of 56 associated SNPs localized to the overlapping promoter regions of PARK2/PACRG. For this region, multivariate analysis identified four SNPs belonging to two major SNP bins (rs1333955, rs7744433) and two single SNP bins (rs2023004, rs6936895) that capture the combined statistical evidence (P = 1.1 × 10(-5)) for association among Vietnamese patients. Next, we enrolled a case-control sample of 364 leprosy cases and 370 controls from Northern India. We genotyped all subjects for 149 SNPs that capture >80 % of the genetic variation in the Vietnamese sample and found 24 SNPs significantly associated with leprosy. Multivariate analysis identified three SNPs (rs1333955, rs9356058 and rs2023004) that capture the association with leprosy (P < 10(-8)). Hence, two SNPs (rs1333955 and rs2023004) were replicated by multivariate analysis between both ethnic groups. Marked differences in the linkage disequilibrium pattern explained some of the differences in univariate analysis between the two ethnic groups. In addition, the strength of association for two promoter region SNP bins was significantly stronger among young leprosy patients in the Vietnamese sample. The same trend was observed in the Indian sample, but due to the higher age-at-diagnosis of the patients the age effect was less pronounced.
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