Evidence map›Paper›PMID 23052930›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013

Efficacy of home-based virtual cycling training on bone mineral density in ambulatory children with cerebral palsy.

C-L Chen, C-Y Chen, M-Y Liaw, C-Y Chung, C-J Wang, W-H Hong

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Effects of various exercise interventions on motor function in cerebral palsy patients: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  9. Exercise interventions for cerebral palsy.The Cochrane database of systematic reviews · 2017
    Pooled it
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  11. Trial
  12. Article
  13. Review
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  16. Ambulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Cognitive outcomes of the at-home brain balance program.Frontiers in child and adolescent psychiatry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C-L ChenPhysical Medicine and Rehabilitation, Chang Gung Memorial hospital, Linkou, and Graduate Institute of Early Intervention, College of Medicine, Chang Gung University, 5 Fu-Hsing St. Kwei-Shan, Tao-Yuan, 333, Taiwan.
C-Y Chen
M-Y Liaw
C-Y Chung
C-J Wang
W-H Hong

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe 12-week home-based virtual cycling training (hVCT) improved lower limb muscle strength and areal bone mineral density (aBMD) than the control program in children with cerebral palsy (CP). A muscle strengthening program, rather than general physical activity, is more specific in enhancing aBMD for these children. A novel hVCT is an effective and efficient strategy that enhances lower limb bone density in these children.

introductionThis is the first study to assess the efficacy of a novel hVCT program on bone density for children with spastic CP using a well-designed randomized controlled trial.

methodsTwenty-seven ambulatory children with spastic CP, aged 6-12 years, were randomly assigned to the hVCT group (n=13) or control group (n=14). Outcome measures-motor function [Gross Motor Function Measure-66 (GMFM-66)], muscle strength (curl up scores and isokinetic torque of knee extensor and flexor muscle) and aBMD of the lumbar and distal femur-were administered before and immediately after the 12-week intervention.

resultsAnalysis of covariance results show that the hVCT group had greater distal femur aBMD and isokinetic torques of knee extensor and flexor muscles than the control group at posttreatment (p<0.05). However, curl up scores, GMFM-66, and lumbar aBMD at posttreatment did not differ between the two groups.

conclusionsAnalytical findings suggest that the muscle strengthening program is more specific in enhancing bone density for children with CP than general physical activity. Thus, the proposed 12-week hVCT protocol is an effective and efficient strategy for improving lower limb aBMD in these children.

Indexed as

Home Care ServicesBicyclingBone DensityCerebral PalsyChildExercise TherapyFemaleFemurHumansKnee JointMaleMuscle, SkeletalMuscle StrengthRange of Motion, ArticularTreatment OutcomeVirtual Reality Exposure Therapy

Identifiers

PMID23052930

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.