ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Home-based multidimensional survivorship programmes for breast cancer survivors.The Cochrane database of systematic reviews · 2017Pooled it
- Association of catastrophizing and fatigue: a systematic review.Journal of psychosomatic research · 2013Pooled it
- Comparison of neuromuscular fatigability amplitude and etiologies between fatigued and non-fatigued cancer patients.European journal of applied physiology · 2024Trial
- Pre-post analysis of a social capital-based exercise adherence intervention for breast cancer survivors with moderate fatigue: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- Exercise-Induced Circulating Lactate Responses in Breast Cancer Survivors: A Systematic Review and Exploratory Meta-Analysis.Muscles (Basel, Switzerland) · 2026Review
- Tracking cancer-related fatigue during chemotherapy: Insights from a comparative cohort study of early breast cancer patients.International journal of cancer · 2025Article
- Fatigue of Cancer is Distinctly Different than the Fatigue of Chronic Kidney Disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Management of cancer treatment-related fatigue in advanced breast cancer patients: an expert committee's opinion.Frontiers in oncology · 2025Review
- Mechanisms, assessment, and exercise interventions for skeletal muscle dysfunction post-chemotherapy in breast cancer: from inflammation factors to clinical practice.Frontiers in oncology · 2025Review
- Breast cancer survivorship needs: a qualitative study.BMC cancer · 2024Article
- Exacerbated central fatigue and reduced exercise capacity in early-stage breast cancer patients treated with chemotherapy.European journal of applied physiology · 2023Article
- Effect of Combined Training on Body Image, Body Composition and Functional Capacity in Patients with Breast Cancer: Controlled Clinical Trial.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?Frontiers in sports and active living · 2023Review
- Physiological and psychosocial correlates of cancer-related fatigue.Journal of cancer survivorship : research and practice · 2022Article
- Article
- Relationships between Physiological and Self-Reported Assessment of Cancer-Related Fatigue.International journal of exercise science · 2022Article
- Building a biopsychosocial model of cancer-related fatigue: the BIOCARE FActory cohort study protocol.BMC cancer · 2021Article
- Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers.Frontiers in cell and developmental biology · 2021Review
- Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Tailored exercise interventions to reduce fatigue in cancer survivors: study protocol of a randomized controlled trial.BMC cancer · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeFatigue is one of the most commonly reported side effects during treatment for breast cancer and can persist following treatment completion. Cancer-related fatigue after treatment is multifactorial in nature, and one hypothesized mechanism is cardiorespiratory and neuromuscular deconditioning. The purpose of this study was to compare cardiorespiratory and neuromuscular function in breast cancer survivors who had completed treatment and met the specified criteria for cancer-related fatigue and a control group of breast cancer survivors without fatigue.
methodsParticipants in the fatigue (n = 16) and control group (n = 11) performed a maximal exercise test on a cycle ergometer for determination of peak power, power at lactate threshold, and VO(2) peak. Neuromuscular fatigue was induced with a sustained submaximal contraction of the right quadriceps. Central fatigue (failure of voluntary activation) was evaluated using twitch interpolation, and peripheral fatigue was measured with an electrically evoked twitch.
resultsPower at lactate threshold was lower in the fatigue group (p = 0.05). There were no differences between groups for power at lactate threshold as percentage of peak power (p = 0.10) or absolute or relative VO(2) peak (p = 0.08 and 0.33, respectively). When adjusted for age, the fatigue group had a lower power at lactate threshold (p = 0.02) and absolute VO(2) peak (p = 0.03). There were no differences between groups in change in any neuromuscular parameters after the muscle-fatiguing protocol.
conclusionsFindings support the hypothesis that cardiorespiratory deconditioning may play a role in the development and persistence of cancer-related fatigue following treatment. Future research into the use of exercise training to reduce cardiorespiratory deconditioning as a treatment for cancer-related fatigue is warranted to confirm these preliminary findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.