Trial reportDer Nervenarzt2012
[EuroHYP-1 trial: EU-funded therapy study on the effectiveness of mild therapeutic hypothermia for acute ischemic stroke].
Trial report in Der Nervenarzt, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- The Clinical Usefulness of Targeted Temperature Management in Acute Ischemic Stroke with Malignant Trait After Endovascular Thrombectomy.Neurocritical care · 2021Article
- Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons.Neural regeneration research · 2015Article
- Targeted temperature management in brain protection: An evidence-based review.Indian journal of anaesthesia · 2015Article
- Critical care for patients with massive ischemic stroke.Journal of stroke · 2014Review
- [News and perspectives in neurocritical care].Der Nervenarzt · 2014Review
- Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications.The Neurohospitalist · 2014Article
- Hypothermia protects human neurons.International journal of stroke : official journal of the International Stroke Society · 2014Article
- In cold blood: intraarteral cold infusions for selective brain cooling in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Neuroprotection in stroke: past, present, and future.ISRN neurology · 2014Review
- [Increased intracranial pressure and brain edema].Der Anaesthesist · 2013Review
- [Increased intracranial pressure and brain edema].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic hypothermia (TH) improves the neurological outcome in experimental brain trauma models as well as in patients suffering from cardiac arrest and perinatal asphyxia. So far the efficacy of TH has not been proven in acute ischemic stroke due to lack of clinical data. The EuroHYP-1 study will investigate whether TH with an individual target range temperature between 34 and 35 °C administered for 24 h will improve the neurological outcome in ischemic stroke patients treated within 6 h from symptom onset. The target patient number of 1,500 to be included in EuroHYP-1 is sufficiently powered to detect the efficacy of TH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.