ArticleThe Journal of membrane biology2013
Therapeutic potential of some plant extracts used in Turkish traditional medicine on streptozocin-induced type 1 diabetes mellitus in rats.
Article in The Journal of membrane biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of Ethanolic Lyophilized and Nanoparticle Extracts of Cilo Wormwood (Artemisia haussknechtii Boiss.) Leaves on Histopathological Findings Antioxidant Defence System and Serum Biomarker Constituents in Diabetic Rats.Applied biochemistry and biotechnology · 2026Article
- Diosmin or Hesperidin? Comparison of Antioxidative Action of Two Venoactive Flavonoids in Type 1 Diabetic Rats.International journal of molecular sciences · 2025Article
- Evaluation of the toxicity potential of exercise and atorvastatin/metformin combination therapy on STZ-diabetic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Golden thistle (Food science & nutrition · 2023Article
- Exercise-related alterations in MCT1 and GLUT4 expressions in the liver and pancreas of rats with STZ-induced diabetes.Journal of diabetes and metabolic disorders · 2023Article
- Determination of Caffeoylquinic Acids Content by UHPLC inPlants (Basel, Switzerland) · 2023Article
- Bioactivity and antidiabetic properties ofHeliyon · 2022Article
- Effects ofTurkish journal of ophthalmology · 2021Article
- Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening.Molecules (Basel, Switzerland) · 2019Review
- Addition of the Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m to Prolonged and Moderate Exercise Training Enhanced Protection of the Rat Heart From Type-1 Diabetes.Frontiers in pharmacology · 2019Article
- Effect of Catha edulis (khat) on pancreatic functions in streptozotocin-induced diabetes in male Sprague-Dawley rats.Experimental animals · 2018Article
- Antioxidant Activity ofMedicines (Basel, Switzerland) · 2018Review
- In vivo screening and evaluation of four herbs against MRSA infections.BMC complementary and alternative medicine · 2017Article
- Potential Use of Turkish Medicinal Plants in the Treatment of Various Diseases.Molecules (Basel, Switzerland) · 2016Review
- The use of complementary medicine in patients with diabetes.Northern clinics of Istanbul · 2016Article
- Effects of pharmaceutical formulations containing thyme on carbon tetrachloride-induced liver injury in rats.BMC complementary and alternative medicine · 2015Article
- Herbal therapy: A review of emerging pharmacological tools in the management of diabetes mellitus in Africa.Pharmacognosy magazine · 2015Article
- Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus.BMC complementary and alternative medicine · 2014Article
- Effect of exercise training of different intensities on anti-inflammatory reaction in streptozotocin-induced diabetic rats.Biology of sport · 2014Article
- Tracing fasting glucose fluxes with unstressed catheter approach in streptozotocin induced diabetic rats.Journal of diabetes research · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) is known to impair many physiological functions. Some reports claim that medicinal plants can reduce these alterations caused by DM. The aim of this study was to investigate the therapeutic potential of aqueous-methanol extracts of Urtica dioica, Thymus vulgaris (TV), Myrtus communis (MC), Scolymus hispanicus (SH) and Cinnamomun zeylanicum (CZ) on streptozotocin (STZ)-induced type 1 DM in rats. Diabetes was induced via a single i.p. injection of STZ (65 mg/kg body weight). After 1 week to allow for development of diabetes, each plant extract was administered to diabetic rats separately at a dose of 100 mg/kg body weight daily for 28 days. The results showed that only SH extract significantly (P < 0.05) amended fasting blood glucose level. The lipid profile was ameliorated especially by supplementations of TV, MC and CZ extracts. Almost all plant extract treatments markedly (P < 0.05) increased reduced glutathione content and decreased lipid peroxidation levels of erythrocyte, plasma, retina and lens tissues. They also significantly (P < 0.05) amended erythrocyte catalase activity, levels of marker serum enzymes (except amylase), urea and blood urea nitrogen when compared to diabetic rats treated with nothing. Furthermore, none of the plant extracts counteracted body weight loss of diabetic rats. Our data revealed that the aforementioned plant extracts have remarkable potential to counteract DM-caused alterations, probably through their antioxidant and free radical-defusing effects.
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