ArticleWorld journal of surgery2013
Effect of obesity and decompressive laparotomy on mortality in acute pancreatitis requiring intensive care unit admission.
Article in World journal of surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Fever on hospital admission is associated with increased disease severity and mortality in acute pancreatitis: a systematic review and meta-analysis.Systematic reviews · 2026Pooled it
- Metabolic syndrome components individually worsen the outcome of acute pancreatitis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox.Science advances · 2021Pooled it
- Timing of surgical intervention for compartment syndrome in different body region: systematic review of the literature.World journal of emergency surgery : WJES · 2020Pooled it
- Risk factors for intra-abdominal hypertension and abdominal compartment syndrome among adult intensive care unit patients: a systematic review and meta-analysis.Critical care (London, England) · 2013Pooled it
- Obesity as a risk factor for severe acute pancreatitis patients.Wiener klinische Wochenschrift · 2014Trial
- The effect of serum lipase levels on clinical severity scores and mortality in acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2026Article
- Surgical decompression for the management of abdominal compartment syndrome with severe acute pancreatitis: A narrative review.World journal of gastrointestinal surgery · 2023Review
- Intra-abdominal hypertension and abdominal compartment syndrome in acute pancreatitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Review
- Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis.Life (Basel, Switzerland) · 2023Article
- Obesity and alcoholic etiology as risk factors for multisystem organ failure in acute pancreatitis: Multinational study.United European gastroenterology journal · 2023Observational
- Abdominal Compartment Syndrome in Acute Pancreatitis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- Abdominal compartment syndrome: an often overlooked cause of acute kidney injury.Journal of nephrology · 2022Review
- Abdominal Compartment Syndrome-When Is Surgical Decompression Needed?Diagnostics (Basel, Switzerland) · 2021Review
- Excess Body Weight and Pancreatic Disease.Visceral medicine · 2021Review
- Who would benefit from open abdomen in severe acute pancreatitis?-a matched case-control study.World journal of emergency surgery : WJES · 2021Article
- Severe pancreatitis complicated by abdominal compartment syndrome managed with decompressive laparotomy: a case report.BMC surgery · 2019Article
- Decompressive laparotomy for abdominal compartment syndrome resulting from severe acute pancreatitis: a case report.BMC gastroenterology · 2019Article
- Mortality predictors of patients suffering of acute pancreatitis and development of intraabdominal hypertensionTurkish journal of medical sciences · 2019Article
- Abdominal Compartment Syndrome as a Multidisciplinary Challenge. A Literature Review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundControversy still exists on the effect that obesity has on the morbidity and mortality in severe acute pancreatitis (SAP). The primary purpose of this study was to compare the mortality rate of obese versus nonobese patients admitted to the ICU for SAP. Secondary goals were to assess the potential risk factors for abdominal compartment syndrome (ACS) and to investigate the performance of validated scoring systems to predict ACS and in-hospital mortality.
methodsA retrospective cohort of adults admitted to the ICU for SAP was stratified by their body mass index (BMI) as obese and nonobese. The rates of morbidity, mortality, and ACS were compared by univariate and multivariate regression analyses. Areas under the curve (AUC) were used to evaluate the discriminating performance of severity scores and other selected variables to predict mortality and the risk of ACS.
resultForty-five patients satisfied the inclusion criteria and 24 (53 %) were obese with similar characteristics to nonobese patients. Among all the subjects, 11 (24 %) died and 16 (35 %) developed ACS. In-hospital mortality was significantly lower for obese patients (12.5 vs. 38 %; P = 0.046) even though they seemed to develop ACS more frequently (41 vs. 28 %; P = 0.533). At multivariable analysis, age was the most significant factor associated with in-hospital mortality (odds ratio (OR) = 1.273; 95 % confidence interval (CI) 1.052-1.541; P = 0.013) and APACHE II and Glasgow-Imrie for the development of ACS (OR = 1.143; 95 % CI 1.012-1.292; P = 0.032 and OR = 1.221; 95 % CI 1.000-1.493; P = 0.05) respectively. Good discrimination for in-hospital mortality was observed for patients' age (AUC = 0.846) and number of comorbidities (AUC = 0.801). ACS was not adequately predicted by any of the clinical severity scores (AUC = 0.548-0.661).
conclusionsPatients' age was the most significant factor associated with mortality in patients affected by SAP. Higher APACHE II and Glasgow-Imrie scores were associated with the development of ACS, but their discrimination performance was unsatisfactory.
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