ArticleSurgery today2013
Differences in the expression of epithelial-mesenchymal transition related molecules between primary tumors and pulmonary metastatic tumors in colorectal cancer.
Article in Surgery today, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Smad4 and epithelial-mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical study.Journal of molecular histology · 2018Article
- Overexpression of FAM3C protein as a novel biomarker for epithelial-mesenchymal transition and poor outcome in gastric cancer.International journal of clinical and experimental pathology · 2018Article
- Blood serum levels of E-cadherin in patients with colorectal cancer.Przeglad gastroenterologiczny · 2017Article
- Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.Surgery today · 2015Article
- Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer.Frontiers in oncology · 2015Review
- Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome.World journal of gastroenterology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
purposeEpithelial-mesenchymal transition (EMT) is a key event in cancer metastasis. This study immunohistochemically examined the expression of EMT-related molecules in both primary colorectal cancer and pulmonary metastases, and analyzed the expression pattern.
methodsTen patients with colorectal cancer that underwent surgical resections for both the primary tumor and metastatic pulmonary tumors were included. The expression status of EMT-related molecules was examined using immunohistochemical staining.
resultsNine of the 10 cases maintained the expression of both E-cadherin and β-catenin in the primary site. The expression of E-cadherin and β-catenin in the pulmonary metastatic site was preserved in 10 and 12 out of 15 metastatic lesions, respectively. The EMT-related transcription factor, Twist, was positively expressed in all 10 cases, Smad interacting protein 1 (Sip1) in 9, Snail in 4 and Slug in 3 of the primary sites. On the other hand, staining for Twist, Sip1 and Snail at the metastatic pulmonary site, was negative in all 10 cases.
conclusionThe expression of EMT-related transcription factors in metastatic pulmonary tumors from colorectal cancer decreased in comparison to the primary tumors. These findings suggested that the expression status of EMT-related transcription factors might play an important role in the implantation of metastatic foci.
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