Trial reportPediatric nephrology (Berlin, Germany)2013
The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis.
Trial report in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Pooled it
- The effect of vitamin A on renal damage following acute pyelonephritis in children: a meta-analysis of randomized controlled trials.Pediatric nephrology (Berlin, Germany) · 2016Pooled it
- The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2013Trial
- The Role of Vitamins in Pediatric Urinary Tract Infection: Mechanisms and Integrative Strategies.Biomolecules · 2025Review
- Chronic Kidney Disease Diets for Kidney Failure Prevention: Insights from the IL-11 Paradigm.Nutrients · 2024Review
- Collecting duct cells show differential retinoic acid responses to acute versus chronic kidney injury stimuli.Scientific reports · 2020Article
- Consequences of Vitamin A Deficiency: Immunoglobulin Dysregulation, Squamous Cell Metaplasia, Infectious Disease, and Death.International journal of molecular sciences · 2020Article
- Antimicrobial Pharmacotherapy Management of Urinary Tract Infections in Pediatric Patients.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2018Review
- Kidney tubular cell protection; recent findings.Iranian journal of pediatrics · 2014Article
- Can postpyelonephritic renal scarring be prevented?Pediatric nephrology (Berlin, Germany) · 2013Article
- Use of antioxidants in urinary tract infection.Journal of research in pharmacy practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous factors may contribute to renal tissue injury after urinary tract infection. We have evaluated the effects of vitamins A or E supplementation in combination with antibiotics for the prevention of renal scarring in acute pyelonephritis.
methodsA simple non-blind randomized clinical trial was conducted on 61 children aged 1 month to 10 years between 2004 and 2006. The inclusion criteria were positive urine culture, clinical findings, and 99mTc-dimercaptosuccinic acid (DMSA) scintigraphy-based evidence in favor of acute pyelonephritis. The children were randomized into three treatment groups: 10-day treatment with only antibiotics (control group; n = 25) and 10-day treatment with supplements of vitamin A (n = 17) or vitamin E (n = 18) in addition to antibiotics during the acute phase of infection. The final analysis was performed after excluding male patients. Each patient was evaluated twice by 99mTc-DMSA scintigraphy performed at least 6 months apart. P < 0.05 was considered to be statistically significant.
resultsThe analysis included 108 kidney units. The frequency of inflammation at the beginning of therapy was not significantly different in the three groups (63.3 % in vitamin A, 61 % in vitamin E, and 76.2 % in the control group). A worsening of lesions, based on the second 99mTc-DMSA scan, was observed in 42.5, 0, and 23.3 % of the control, vitamin E, and vitamin A patients, respectively (LR = 26.3, P < 0.001).
conclusionVitamins A or E supplements were effective in reducing renal scarring secondary to acute pyelonephritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.