ArticlePediatric nephrology (Berlin, Germany)2013
Prevalence of genetic renal disease in children.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol.BMC nephrology · 2025Article
- A guide to gene-disease relationships in nephrology.Nature reviews. Nephrology · 2025Review
- Genetic Testing in the Pediatric Nephrology Clinic: Understanding Families' Experiences.Journal of pediatric genetics · 2022Article
- Advances in our understanding of genetic kidney disease using kidney organoids.Pediatric nephrology (Berlin, Germany) · 2020Review
- Recapitulating kidney development: Progress and challenges.Seminars in cell & developmental biology · 2019Review
- Renal genetics in Australia: Kidney medicine in the genomic age.Nephrology (Carlton, Vic.) · 2019Review
- Congenital Anomalies of the Kidney and Urinary Tract: A Clinical Review.Current treatment options in pediatrics · 2019Article
- Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.American journal of human genetics · 2018Article
- A questionnaire survey of radiological diagnosis and management of renal dysplasia in children.Journal of nephrology · 2018Article
- Analysis of the IL-10, IL-12, and TNF-α Gene Polymorphisms in Patients With Vesicoureteral Reflux Among the Southeast Iranian Population.Nephro-urology monthly · 2016Article
- A protocol for the identification and validation of novel genetic causes of kidney disease.BMC nephrology · 2015Article
- Oral conditions in renal disorders and treatment considerations - A review for pediatric dentist.The Saudi dental journal · 2015Review
- Genomics in the renal clinic - translating nephrogenetics for clinical practice.Human genomics · 2015Article
- Next-generation sequencing for research and diagnostics in kidney disease.Nature reviews. Nephrology · 2014Review
- PAX2 polymorphisms and congenital abnormalities of the kidney and urinary tract in a Brazilian pediatric population: evidence for a role in vesicoureteral reflux.Molecular diagnosis & therapy · 2014Article
- The prevalence and epidemiology of genetic renal disease amongst adults with chronic kidney disease in Australia.Orphanet journal of rare diseases · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic etiology comprises a significant proportion of renal disease in childhood. Completion of the Human Genome Project and increased genetic testing has assisted with the increased recognition of a genetic basis to many renal disorders. Australia and New Zealand have a relatively stable but diverse population, with eight major pediatric nephrology referral centers, which allow ascertainment of disease frequency.
methodsTo determine prevalence, pediatric nephrologists at the eight centers in Australia and New Zealand were surveyed on their estimated number of patients with renal disease of genetic etiology over a 10-year period. Disease prevalence was calculated using combined national population data.
resultsThe overall prevalence of genetic kidney disease in children in Australia and New Zealand is 70.6 children per million age-representative population. Congenital anomalies of the kidney and urinary tract (CAKUT) and steroid-resistant nephrotic syndrome (SRNS) are the most frequent, with a prevalence of 16.3 and 10.7, respectively, per million children.
conclusionWe find a similar prevalence of genetic renal disorders in Australia and New Zealand to those reported in other countries. This is likely to be due to inclusion of children with all forms of renal disease rather than being limited to those with renal impairment.
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