ArticleEuropean radiology2013
Digital mammography screening: how many breast cancers are additionally detected by bilateral ultrasound examination during assessment?
Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.The Cochrane database of systematic reviews · 2023Pooled it
- Between-race differences in the effects of breast density information and information about new imaging technology on breast-health decision-making.Patient education and counseling · 2016Trial
- Application of computer-aided diagnosis to predict malignancy in BI-RADS 3 breast lesions.Heliyon · 2024Article
- Photoacoustic breast tomography prototypes with reported human applications.European radiology · 2015Review
- In reply.Deutsches Arzteblatt international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the positive predictive values of incremental breast cancer detection (PPV1) in relation to the mammographic breast density and of performed biopsies (PPV3) resulting from supplemental bilateral physician-performed whole-breast ultrasound (US) at recall of a population-based digital mammography screening programme.
methodsA total of 2,803 recalled screening participants (50-69 years), who had additional bilateral US with prospectively completed documentation [grading of breast density (ACR 1-4), biopsy recommendation related to US and mammography], were included.
resultsThe PPV1 of supplemental cancer detection only by US was 0.21 % (6/2,803) compared to 13.8 % (386/2,803) by mammography. The PPV1 of US-only cancer detection was 0 %, 0.16 % (2/1,220), 0.22 % (3/1,374) and 1.06 % (1/94) for women with breast density of ACR 1, ACR 2, ACR 3 and ACR 4, respectively. The PPV3 of US-only lesion detection was 33.3 % (9/27) compared to 38.0 % (405/1,066) by mammography. The proportion of invasive cancers no larger than 10 mm was 37.5 % (3/8) for US-only detection compared to 38.4 % (113/294) for mammographic detection.
conclusionBilateral ultrasound at recall, in addition to the assessment of screen-detected mammographic abnormalities, resulted in a low PPV of incremental cancer detection only by US, without a disproportional increase of false-positive biopsies.
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Registered trials
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