Trial reportEuropean journal of nutrition2013
Effects of 5 % weight loss through diet or diet plus exercise on cardiovascular parameters of obese: a randomized clinical trial.
Trial report in European journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of dietary-based weight loss interventions on biomarkers of endothelial function: a systematic review and meta-analysis.European journal of clinical nutrition · 2023Pooled it
- Meta-Analysis of the Effect of Different Exercise Mode on Carotid Atherosclerosis.International journal of environmental research and public health · 2023Pooled it
- Lifestyle-Induced Visceral Fat Loss as a Key Target for Durable Cardiometabolic Health: MRI-Assessed 5- and 10-Year Follow-Up After 2 Clinical Trials.Circulation · 2026Trial
- Trial
- A multifunctional diet improves cardiometabolic-related biomarkers independently of weight changes: an 8-week randomized controlled intervention in healthy overweight and obese subjects.European journal of nutrition · 2016Trial
- IQP-GC-101 reduces body weight and body fat mass: a randomized, double-blind, placebo-controlled study.Phytotherapy research : PTR · 2014Trial
- Usefulness of Nutritional Intervention Through New Digital Technologies in Patients with Inflammatory Bowel Disease.Nutrients · 2026Article
- Association of Dietary Fiber and Measures of Physical Fitness with High-Sensitivity C-Reactive Protein.Nutrients · 2024Article
- Integration of Endogenous Opioid System Research in the Interprofessional Diagnosis and Treatment of Obesity and Eating Disorders.Advances in neurobiology · 2024Article
- Behavioral Weight Loss and Maintenance: A 25-Year Research Program Informing Innovative Programming.The Permanente journal · 2022Review
- Evaluation of PMEnvironmental epidemiology (Philadelphia, Pa.) · 2021Article
- Effects of Exercise on the Body Composition and Lipid Profile of Individuals with Obesity: A Systematic Review and Meta-Analysis.Journal of obesity & metabolic syndrome · 2019Article
- Article
- Efficacy and safety ofTherapeutics and clinical risk management · 2018Article
- Equivalent reductions in body weight during the Beef WISE Study: beef's role in weight improvement, satisfaction and energy.Obesity science & practice · 2017Article
- Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis.International journal of vascular medicine · 2017Review
- Impact of Dietary and Metabolic Risk Factors on Cardiovascular and Diabetes Mortality in South Asia: Analysis From the 2010 Global Burden of Disease Study.American journal of public health · 2016Article
- Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet.Food & nutrition research · 2016Article
- Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effects of 5 % weight loss, through diet only or diet plus exercise, on lipid profile, inflammation and endothelial function in obese individuals.
methodsIn this randomized clinical trial, 48 obese individuals were randomized to either a diet only group (DI) or a diet and exercise group (DI + EXE). Treatment was maintained until 5 % of the initial body weight was lost. At baseline and upon completion, the following parameters were analyzed: total cholesterol and fractions, triglycerides, fibrinogen, von Willebrand factor, high-sensitive C-reactive protein (hs-CRP) and endothelial function (brachial artery flow-mediated vasodilation-FMD).
resultsThirteen individuals dropped out before completing the weight loss intervention. The median time required for reduction of 5 % of initial body weight was 79.7 days for the DI group and 65.9 days for the DI + EXE group (P = 0.16). In both DI (n = 18) and DI + EXE (n = 17), total cholesterol (-15.8 ± 4.8 and -10.5 ± 4.9 mg/dL, respectively), triglycerides (-33.8 ± 10.0 and -39.4 ± 10.3 mg/dL, respectively) and hs-CRP (-1.35 ± 0.41 and -0.45 ± 0.43 mg/L, respectively) decreased significantly, and in a similar response (repeated measures ANOVA). Weight loss did not change significantly the fibrinogen and FMD in both groups.
conclusionA 5 % weight loss improves lipid profile and reduces inflammation in obese individuals. Endothelial function did not change significantly. Weight loss has a significant impact on these cardiovascular risk factors, and this is independent of physical training.
Indexed as
Identifiers
23052625What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.