ArticleEuropean journal of pediatrics2013
Functional echocardiography in staging for ductal disease severity : role in predicting outcomes.
Article in European journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04508036 (The Relationship of Ductus Arteriosus Closure and D-Dimer and Fibrinogen Levels in Premature Babies), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relationship of Ductus Arteriosus Closure and D-Dimer and Fibrinogen Levels in Premature Babies
Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
- Trial
- Factors affecting N-terminal pro-B-type natriuretic peptide levels in preterm infants and use in determination of haemodynamic significance of patent ductus arteriosus.European journal of pediatrics · 2018Trial
- Artificial intelligence for patent ductus arteriosus-a systematic review.Frontiers in pediatrics · 2026Review
- Heart of the matter: predicting need for PDA surgical ligation from an early echocardiogram.Pediatric research · 2025Article
- Observational
- Personalized Evidence-Based Management of Patent Ductus Arteriosus in Preterm Infants.Journal of cardiovascular development and disease · 2023Review
- The left ventricle in well newborns versus those with perinatal asphyxia, haemodynamically significant ductus arteriosus or fetal growth restriction.Translational pediatrics · 2023Review
- Predictive value of a nomogram model for adverse outcomes in very low birth weight infants with patent ductus arteriosus: A prospective study.Frontiers in pediatrics · 2023Article
- Conservative Management of Patent Ductus Arteriosus Is Feasible in the Peri-Viable Infants at 22-25 Gestational Weeks.Biomedicines · 2022Article
- Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Cardiovascular Dysfunction in Intrauterine Growth Restriction.Current hypertension reports · 2022Review
- Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider.Journal of the American Heart Association · 2022Review
- A Novel Patent Ductus Arteriosus Severity Score to Predict Clinical Outcomes in Premature Neonates.Journal of cardiovascular development and disease · 2022Article
- Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman-Anderson Score, and NT-Pro-BNP Level.Journal of clinical medicine · 2021Article
- Factors affecting the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus in preterm infants.International journal of clinical pharmacy · 2021Article
- Objective Assessment of Physiologic Alterations Associated With Hemodynamically Significant Patent Ductus Arteriosus in Extremely Premature Neonates.Frontiers in pediatrics · 2021Review
- Predictive Model of Early Spontaneous Ductus Arteriosus Closure Based on Neonatologist Performed Echocardiography in Preterm Infants.Frontiers in pediatrics · 2021Article
- Clinical validity of systemic arterial steal among extremely preterm infants with persistent patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- SIMPLE: A Novel Scoring System for Predicting Hemodynamically Significant Patent Ductus Arteriosus Without Echocardiographic Evaluation in Extremely Low Birth Weight Infants.Frontiers in pediatrics · 2021Article
- Size of Patent Ductus Arteriosus and Echocardiographic Markers of Shunt Volume in Preterm Infants Based on Postnatal Age.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledEquipoise persists as to the issue of assigning haemodynamic and clinical significance to a patent ductus arteriosus (PDA). The objective was to ascertain whether echocardiographic scoring of a PDA correlates with outcomes. Unit electronic data base was accessed to identify infants less than 32 weeks' gestation who received ibuprofen for medical closure of the PDA during the period June 2010-June 2012. Echocardiographic score was assigned on the day of therapy and the infants were prospectively followed up to ascertain the occurrence of chronic lung disease (CLD). Logistic regression analysis was used to estimate the association between composite score and occurrence of CLD. Fifty-two infants were identified out of which 27 (52 %) subsequently developed CLD. Echocardiographic parameters were of a significantly higher magnitude in infants who later developed CLD. The median composite score (inter-quartile range) was also significantly higher in this group 26 (24-26) vs. 19 (17-20), p < 0.001). Higher composite scores were associated with increased risk of developing CLD; for every one point increase in composite score, the odds of CLD increased by 78 % (odds ratio (95 % CI): 1.78 (1.35-2.34); p < 0.001).
conclusionsInfants with a high composite score, assigned according to the staging criteria at the time of treatment, were noted to have a higher incidence of subsequent CLD. Whether disease stratification can be the basis of further RCT's needs prospective evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.