ArticleEuropean journal of clinical pharmacology2013
Difficulties swallowing solid oral dosage forms in a general practice population: prevalence, causes, and relationship to dosage forms.
Article in European journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Swallowing Difficulties With Medication Intake and Coping Strategies in Patients With Systemic Sclerosis: a Cross-sectional Cohort Study
Comparison of the Ease of Swallowability of B/F/TAF Placebo Compared to DTG/ABC/3TC Placebo
Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Older adults with difficulty swallowing oral medicines: a systematic review of the literature.European journal of clinical pharmacology · 2016Pooled it
- Trial
- Oral bioavailability of microdoses and therapeutic doses of midazolam as a 2-dimensionally printed orodispersible film in healthy volunteers.European journal of clinical pharmacology · 2022Trial
- Prevalence and patient-rated relevance of complexity factors in medication regimens of community-dwelling patients with polypharmacy.European journal of clinical pharmacology · 2022Trial
- Impact of a High-Fat Meal and Sprinkled Administration on the Bioavailability and Pharmacokinetics of Viloxazine Extended-Release Capsules (QelbreeEuropean journal of drug metabolism and pharmacokinetics · 2022Trial
- Pharmacokinetic similarity demonstrated after crushing of the elbasvir/grazoprevir fixed-dose combination tablet for HCV infection.The Journal of antimicrobial chemotherapy · 2020Trial
- Assessment of Taste and Grittiness of RiometDrugs in R&D · 2019Trial
- Survey of suspected dysphagia prevalence in home-dwelling older people using the 10-Item Eating Assessment Tool (EAT-10).PloS one · 2019Trial
- Two Phase 1, Open-Label, Single-Dose, Randomized, Crossover Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered Granules of Secnidazole (2 g) in Healthy Female Volunteers Under Different Administration Conditions.Clinical pharmacology in drug development · 2018Trial
- An Open-Label Crossover Study of the Pharmacokinetics of the 60-mg Edoxaban Tablet Crushed and Administered Either by a Nasogastric Tube or in Apple Puree in Healthy Adults.Clinical pharmacokinetics · 2018Trial
- Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability.Drug design, development and therapy · 2017Trial
- An open-label, randomized bioavailability study with alternative methods of administration of crushed ticagrelor tablets in healthy volunteers.International journal of clinical pharmacology and therapeutics · 2015Trial
- Pilot study to assess the influence of an enhanced medication plan on patient knowledge at hospital discharge.European journal of clinical pharmacology · 2014Trial
- Two techniques to make swallowing pills easier.Annals of family medicineTrial
- Discriminating Isolated Pill Dysphagia from General Oropharyngeal Dysphagia: Psychometric Properties of the Turkish PILL-5.Dysphagia · 2026Article
- On-Demand Hospital Manufacturing of Baclofen Lozenges Using Pharmaceutical 3D Printing.Pharmaceutical research · 2026Article
- Article
- Prevalence and Characteristics of Pill Dysphagia in Adults with Swallowing Disorders: A FEES Based Retrospective Study.Dysphagia · 2026Article
- Using sentiment analysis to quantify the relative desirability and acceptability of drug-product attributes.JAMIA open · 2026Article
- Challenges in the Oral Administration of Gastro-Resistant Formulations: The Role of Vehicles and Bottled Waters.Pharmaceutics · 2026Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe assessed the prevalence of difficulties in swallowing solid oral dosage forms in a general practice population. Reasons, nature, and characteristics of tablets and capsules causing such difficulties were investigated as well as general practitioners' (GP) awareness of these difficulties.
methodsA questionnaire survey was conducted in 11 general practices and consecutive patients taking at least one solid oral dosage form for ≥4 weeks were invited to respond to a questionnaire at the practices and one at home. Physicians completed a short questionnaire for each included patient.
resultsOf all participants (N = 1,051), 37.4 % reported having had difficulties in swallowing tablets and capsules. The majority (70.4 %) of these patients was not identified by their GP. The occurrence of swallowing difficulties was related to gender (f>m), age (young>old), dysphagia [adjusted odds ratio (adOR): 7.9; p < 0.0001] and mental illness (adOR: 1.8; p < 0.05). By asking "Do you choke while eating or drinking?", affected patients could be identified with a sensitivity of 62.6 % and a specificity of 78.1 %. Because of these difficulties, 58.8 % of the affected patients had already modified their drugs in a way that may alter safety and efficacy and 9.4 % indicated to be non-adherent.
conclusionsOne in 11 primary care patients had frequent difficulties in swallowing tablets and capsules while GPs grossly underestimated these problems. Therefore, physicians should rule out swallowing difficulties regularly to avoid non-adherence and inappropriate drug modifications. Special attention should be paid to specific patient groups (e.g. women and patients with dysphagia, dysphagia indicators, or mental illness).
Indexed as
Identifiers
23052416What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.