ArticleJournal of clinical microbiology2013
Differences between two clinical Staphylococcus capitis subspecies as revealed by biofilm, antibiotic resistance, and pulsed-field gel electrophoresis profiling.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 70 citations in OpenAlex.
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- Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements.Scientific reports · 2025Article
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- Identification of staphyloxanthin and derivates in yellow-pigmentedFrontiers in microbiology · 2023Article
- Isolation and characterization culturable microbes on the surface of 'Granny Smith' apples treated with electrolyzed water during cold storage.Food science and biotechnology · 2022Article
- Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis.Nature communications · 2022Article
- Endogenous endophthalmitis caused by Staphylococcus capitis.American journal of ophthalmology case reports · 2022Article
- Comparative genomics ofFrontiers in microbiology · 2022Article
- Bacteriophage-based decontamination to control environmental colonization byFrontiers in cellular and infection microbiology · 2022Article
- Phenotypic and genomic assessment of the potential threat of human spaceflight-relevantFrontiers in microbiology · 2022Article
- Aerobic Isolates from Gestational and Non-Gestational Lactating Bitches (Animals : an open access journal from MDPI · 2021Article
- Coagulase-Negative Staphylococci Clones Are Widely Distributed in the Hospital and Community.Pathogens (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coagulase-negative staphylococci have been identified as major causes of late-onset neonatal bacteremia in neonatal intensive care units. Sixty isolates of Staphylococcus capitis obtained from blood cultures of neonates between 2000 and 2005 were examined in this study. Biochemical analysis confirmed that 52 of these isolates belonged to the subsp. urealyticus, and the remaining 8 belonged to the subsp. capitis. Isolates of the predominant subsp. urealyticus clones were characterized by their resistance to penicillin, erythromycin, and oxacillin and their biofilm formation ability, whereas subsp. capitis isolates were generally antibiotic susceptible and biofilm negative. Pulsed-field gel electrophoresis (PFGE) after SacII digestion separated the 60 isolates into five major clusters. Sequence analysis showed that, in S. capitis, the ica operon plus the negative regulator icaR was 4,160 bp in length. PCRs demonstrated the presence of the ica operon in all isolates. Further analysis of five isolates (two biofilm-positive subsp. urealyticus, one biofilm-negative subsp. urealyticus, and two biofilm-negative subsp. capitis) revealed that the ica operons were identical in all of the biofilm-positive subsp. urealyticus strains; however, the biofilm-negative isolates showed variations. The distinctive phenotypic and genotypic characteristics revealed by this study may affect the epidemiology of the two subspecies of S. capitis in the clinical setting. These results may provide a better understanding of the contribution of these two species to bloodstream infections in neonates.
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