ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2013
Anti-arthritic activity of the Indian leafy vegetable Cardiospermum halicacabum in Wistar rats and UPLC-QTOF-MS/MS identification of the putative active phenolic components.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- Phytochemical Investigation and Biological Evaluation of Disynaphia filifolia: A Novel Source of Tremetone in Asteraceae.Chemistry & biodiversity · 2025Article
- Comprehensive analysis of complete Chloroplast genome sequence of Cardiospermum halicacabum L. (Sapindaceae).Scientific reports · 2025Article
- Molecular docking analysis of IL-6 and TNF-alpha with phytochemicals fromBioinformation · 2025Article
- Pathogenesis of rheumatoid arthritis and its treatment with anti-inflammatory natural products.Molecular biology reports · 2023Review
- Luteolin-7-Nutrients · 2022Article
- Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling.BMC complementary medicine and therapies · 2022Article
- Anti-rheumatic activity of pseudoephedrine (a substituted phenethylamine) in complete Freund's adjuvant-induced arthritic rats by down regulating IL-1β, IL-6 and TNF-α as well as upregulating IL-4 and IL-10.Inflammopharmacology · 2021Article
- Appraisal of disease-modifying potential of amlodipine as an anti-arthritic agent: new indication for an old drug.Inflammopharmacology · 2020Article
- The Antialgal Mechanism of Luteolin-7-O-Glucuronide onInternational journal of environmental research and public health · 2019Article
- Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides.International journal of environmental research and public health · 2019Article
- In silico validation of the indigenous knowledge of the herbal medicines among tribal communities in Sathyamangalam wildlife sanctuary, India.Journal of traditional and complementary medicine · 2019Article
- In Vivo and In Vitro Anti-Arthritic Effects of Cardenolide-Rich and Caffeoylquinic Acid-Rich Fractions ofMolecules (Basel, Switzerland) · 2018Article
- Identification of Hypotensive Biofunctional Compounds ofOxidative medicine and cellular longevity · 2018Article
- Article
- Simultaneous Extraction and Identification of Phenolic Compounds inFrontiers in plant science · 2017Article
- Chemical Constituents and Antimicrobial Activity of Indian Green Leafy Vegetable Cardiospermum halicacabum.Indian journal of microbiology · 2013Article
- Medicinal plants with potential anti-arthritic activity.Journal of intercultural ethnopharmacologyArticle
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present work was carried out to investigate the free radical scavenging activity of the ethanol extract of C. halicacabum leaves (EECH), to study its antioxidant properties and anti-rheumatic effects in Wistar rats with CFA-induced arthritis, and to profile the phenolic components thereof by LC-MS/MS.
methodsThe free radical scavenging activities of the extract was evaluated by NO and superoxide anion scavenging assays. Arthritis was induced to the albino Wistar rats by CFA. Fifteen days after CFA induction, arthritic rats received EECH orally at the doses of 250 and 500 mg/kg daily for 20 days. Diclofenac sodium was used as reference standard. EECH is subjected to LC-MS/MS analysis for the identification of phenolic compounds.
resultsThe IC(50) value of the EECH to scavenge the NO and superoxide radicals are 83 and 60 μg/ml respectively. Ultrasonography and histology images of hind limb in EECH treated groups confirmed the complete cartilage regeneration. The LC/MS/MS analysis indicated the presence of anti-inflammatory compounds luteolin-7-O-glucuronide, apigenin-7-O-glucuronide and chrysoeriol.
conclusionThese findings lend pharmacological support to the reported folkloric use of C. halicacabum in the treatment and management of painful, arthritic inflammatory conditions.
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