Evidence map›Paper›PMID 23052052›Full record

ArticleDiabetologia2013

The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study.

InterAct Consortium, R A Scott, C Langenberg, S J Sharp, P W Franks, O Rolandsson, D Drogan, Y T van der Schouw, U Ekelund, N D Kerrison and 37 more

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In one paragraph

Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  8. Effects of a family diabetes self-management education intervention on the patients' supporters.Families, systems & health : the journal of collaborative family healthcare · 2020
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

InterAct Consortium
R A Scott
C Langenberg
S J Sharp
P W Franks
O Rolandsson
D Drogan
Y T van der Schouw
U Ekelund
N D Kerrison
E Ardanaz
L Arriola
B Balkau
A Barricarte
I Barroso
B Bendinelli
J W J Beulens
H Boeing
B de Lauzon-Guillain
P Deloukas
G Fagherazzi
C Gonzalez
S J Griffin
L C Groop
J Halkjaer
J M Huerta
R Kaaks
K T Khaw
V Krogh
P M Nilsson
T Norat
K Overvad
S Panico
L Rodriguez-Suarez
D Romaguera
I Romieu
C Sacerdote
M J Sánchez
A M W Spijkerman
B Teucher
A Tjonneland
R Tumino
D L van der A
P A Wark
M I McCarthy
E Riboli
N J Wareham

Funding

Cancer Research UKMedical Research Council G0401527Medical Research Council G0601261Medical Research Council G1000143Medical Research Council MC_U106179473Medical Research Council MC_U106179474Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/3Medical Research Council MC_UU_12015/4Wellcome Trust 083270/Z/07/ZWellcome Trust 090532Wellcome Trust 098051
6 · The paper itself

Abstract

aims/hypothesisAlthough a family history of type 2 diabetes is a strong risk factor for the disease, the factors mediating this excess risk are poorly understood. In the InterAct case-cohort study, we investigated the association between a family history of diabetes among different family members and the incidence of type 2 diabetes, as well as the extent to which genetic, anthropometric and lifestyle risk factors mediated this association.

methodsA total of 13,869 individuals (including 6,168 incident cases of type 2 diabetes) had family history data available, and 6,887 individuals had complete data on all mediators. Country-specific Prentice-weighted Cox models were fitted within country, and HRs were combined using random effects meta-analysis. Lifestyle and anthropometric measurements were performed at baseline, and a genetic risk score comprising 35 polymorphisms associated with type 2 diabetes was created.

resultsA family history of type 2 diabetes was associated with a higher incidence of the condition (HR 2.72, 95% CI 2.48, 2.99). Adjustment for established risk factors including BMI and waist circumference only modestly attenuated this association (HR 2.44, 95% CI 2.03, 2.95); the genetic score alone explained only 2% of the family history-associated risk of type 2 diabetes. The greatest risk of type 2 diabetes was observed in those with a biparental history of type 2 diabetes (HR 5.14, 95% CI 3.74, 7.07) and those whose parents had been diagnosed with diabetes at a younger age (<50 years; HR 4.69, 95% CI 3.35, 6.58), an effect largely confined to a maternal family history. CONCLUSIONS/

interpretationProminent lifestyle, anthropometric and genetic risk factors explained only a marginal proportion of the excess risk associated with family history, highlighting the fact that family history remains a strong, independent and easily assessed risk factor for type 2 diabetes. Discovering factors that will explain the association of family history with type 2 diabetes risk will provide important insight into the aetiology of type 2 diabetes.

Indexed as

Family HealthLife StyleMotor ActivityAdultAgedAged, 80 and overBody Mass IndexCase-Control StudiesCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2EuropeFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHumans

Identifiers

PMID23052052
PMCPMC4038917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.