ArticleAnalytical chemistry2012
High-performance binary protein interaction screening in a microfluidic format.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Quantifying protein unfolding kinetics with a high-throughput microfluidic platform.Cell systems · 2026Article
- Systematic reconstruction of binding and stability landscapes of the fluorogenic aptamer spinach.Nucleic acids research · 2015Article
- An off-the-shelf integrated microfluidic device comprising self-assembled monolayers for protein array experiments.Biomicrofluidics · 2015Article
- Prototyping of poly(dimethylsiloxane) interfaces for flow gating, reagent mixing, and tubing connection in capillary electrophoresis.Journal of chromatography. A · 2014Article
- Proximity ligation assay for high-content profiling of cell signaling pathways on a microfluidic chip.Molecular & cellular proteomics : MCP · 2013Article
- Chip in a lab: Microfluidics for next generation life science research.Biomicrofluidics · 2013Article
- Ligand-based receptor identification on living cells and tissues using TRICEPS.Nature protocols · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The standard procedure to increase microfluidic chip performance is to grow the number of parallel test systems on the chip. This process is accompanied by miniaturizing biochemical workflows and micromechanical elements, which is often a major challenge for both engineering fields. In this work, we show that it is possible to substantially increase the runtime performance of a microfluidic affinity assay for protein interactions by simultaneously engineering fluid logics and assay chemistry. For this, synergistic effects between the micro- and chemical architecture of the chip are exploited. The presented strategy of reducing the runtime rather than size and volume of the mechanical elements and biological reagent compartments will, in general, be of importance for future analytical test systems on microfluidic chips to overcome performance barriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.