Evidence map›Paper›PMID 23050987›Full record

ArticleThe Journal of organic chemistry2012

Automated solid-phase synthesis of RNA oligonucleotides containing a nonbridging phosphorodithioate linkage via phosphorothioamidites.

Nan-Sheng Li, John K Frederiksen, Joseph A Piccirilli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Solid-Phase Synthesis of RNA Analogs Containing Phosphorodithioate Linkages.Current protocols in nucleic acid chemistry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nan-Sheng LiDepartment of Biochemistry & Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States. nli@uchicago.edu
John K Frederiksen
Joseph A Piccirilli

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
The Catalytic Mechanism of Nuclear Premessenger RNA Splicing by the SpliceosomeR01GM088656 · NIGMS · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY, STALEY, JONATHAN P · 2010 to 2017
$4.2M
Investigating the Catalytic Mechanism of the HDV RibozymeR01AI081987 · NIAID · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY · 2010 to 2014
$1.8M
NIAID NIH HHS 1R01AI081987NIAID NIH HHS R01 AI081987NIGMS NIH HHS 5 T32 GM07281NIGMS NIH HHS R01 GM088656NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

This work describes a general method for the synthesis of oligoribonucleotides containing a site-specific nonbridging phosphorodithioate linkage via automated solid-phase synthesis using 5'-O-DMTr-2'-O-TBS-ribonucleoside 3'-N,N-dimethyl-S-(2,4-dichlorobenzyl) phosphorothioamidites (2a-2d). The 3'-phosphorothioamidites (2a-2d) can be conveniently prepared in good yields (86-99%) via a one-pot reaction from the corresponding 5'-O-DMTr-2'-O-TBS-ribonucleosides (1a-1d).

Indexed as

Base SequenceMolecular StructureOligonucleotidesOrganophosphorus CompoundsOrganothiophosphorus CompoundsPhosphatesRibonucleosidesRNASolid-Phase Synthesis TechniquesOligonucleotidesOrganophosphorus CompoundsOrganothiophosphorus CompoundsPhosphatesphosphoramiditephosphorodithioic acidRibonucleosidesRNA

Identifiers

PMID23050987
PMCPMC3500914

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.