Trial reportBMC psychiatry2012
Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial.
Trial report in BMC psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies.BMC public health · 2014Pooled it
- Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial.Brain imaging and behavior · 2021Trial
- A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study.Journal of Alzheimer's disease : JAD · 2019Trial
- Trial
- Relationship between different physical activity parameters and cognitive impairment in middle-aged and older adults: insights from a 4-year longitudinal study.BMC psychology · 2025Article
- Physical Activity Component of the Greek Interventional Geriatric Study to Prevent Cognitive Impairment and Disability (GINGER): Protocol Development and Feasibility Study.Healthcare (Basel, Switzerland) · 2024Article
- The Impact of Hypertension on Cognitive Decline and Alzheimer's Disease and Its Management: A Systematic Review.Cureus · 2024Review
- Vision impairment, hearing impairment and functional Limitations of subjective cognitive decline: a population-based study.BMC geriatrics · 2023Article
- The Association between the Binding Processes of Working Memory and Vascular Risk Profile in Adults.Brain sciences · 2021Article
- Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.Frontiers in aging neuroscience · 2021Article
- MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?Ageing research reviews · 2020Review
- Association between Cognitive Function and Clustered Cardiovascular Risk of Metabolic Syndrome in Older Adults at Risk of Cognitive Decline.The journal of nutrition, health & aging · 2020Article
- Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
- Strategies for dementia prevention: latest evidence and implications.Therapeutic advances in chronic disease · 2017Review
- Increased Physical Fitness Is Associated with Higher Executive Functioning in People with Dementia.Frontiers in public health · 2017Article
- Relation between aerobic fitness and brain structures in amnestic mild cognitive impairment elderly.Age (Dordrecht, Netherlands) · 2016Article
- Alterations in dorsal and ventral posterior cingulate connectivity in APOEBJPsych open · 2015Article
- The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial.Alzheimer's & dementia (New York, N. Y.) · 2015Article
- White matter hyperintensities, cognitive impairment and dementia: an update.Nature reviews. Neurology · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlder adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter hyperintensities (WMH) are associated with VRF, SMC and cognitive impairment. Findings from a growing number of clinical trials with older adults are providing strong evidence for the benefits of physical activity for maintaining cognitive function, but few studies are investigating these benefits in high-risk populations. The aim of AIBL Active is to determine whether a 24-month physical activity program can delay the progression of white matter changes on magnetic resonance imaging (MRI). METHODS/
designThis single-blind randomized controlled trial (RCT) is offered to 156 participants, aged 60 and older, in the Melbourne arm of the Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL). Participants must have SMC with or without MCI and at least one VRF. The PA intervention is a modification of the intervention previously trialed in older adults with SMC and MCI (Fitness for the Ageing Brain Study). It comprises 24 months of moderate, home-based PA (150 minutes per week) and a behavioral intervention package. The primary outcome measure will be change in WMH after 24 months on MRI. Cognition, quality of life, functional fitness, level of physical activity, plasma biomarkers for cerebrovascular disease and amyloid positron emission tomography (PET) imaging comprise secondary measures. DISCUSSION: Currently, there is no effective pharmacological treatment available to delay cognitive decline and dementia in older adults at risk. Should our findings show that physical activity can slow down the progression of WMH, this RCT would provide an important proof of concept. Since imbedded in AIBL this RCT will also be able to investigate the interaction between vascular and Alzheimer's disease pathologies.
trial registrationAustralia New Zealand Clinical Trials Registry ACTRN12611000612910.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.