ArticleBMC neurology2012
Memory and Executive Screening (MES): a brief cognitive test for detecting mild cognitive impairment.
Article in BMC neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brief cognitive screening instruments for early detection of Alzheimer's disease: a systematic review.Alzheimer's research & therapy · 2019Pooled it
- The Effects of Remimazolam Tosylate on Postoperative Memory Function in Young and Middle-Aged Patients Undergoing Laparoscopic Surgery.Drug design, development and therapy · 2026Trial
- Plasma GFAP modifies the association of depressive symptoms with cognitive function: A population-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease.iScience · 2026Article
- A WeChat mini-program-based perioperative cognitive management tool (WACDAM): development and clinical evaluation in elderly patients undergoing oromaxillofacial malignancy surgery-a mixed-methods study.Perioperative medicine (London, England) · 2026Article
- Brain functional connectivity network alterations in occupational aluminum exposure among workers with mild cognitive impairment.Scientific reports · 2026Article
- Cognitive Improvement in Methamphetamine-Dependent Males: A Randomized Trial Comparing Different Exercise Interventions with Behavioral and fNIRS Evidence.Brain sciences · 2026Article
- Implementing plasma p-tau217 and cognitive testing for Alzheimer's screening in low-education populations in central China.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer's disease.Scientific reports · 2025Article
- The cerebellar glucose metabolism in moyamoya vasculopathy and its correlation with neurocognitive performance after cerebral revascularization surgery: a [European journal of nuclear medicine and molecular imaging · 2025Article
- Non-Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations.Frontiers in neuroscience · 2025Article
- Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- APOEε4 Carriers Exhibit Objective Cognitive Deficits: A Cross-Sectional Study in a Single Center Trial.Brain sciences · 2024Article
- The Value of Subjective Olfactometry as a Predictive Biomarker of Neurodegenerative Diseases: A Systematic Review.Life (Basel, Switzerland) · 2024Review
- Visual Cognitive Assessment Test: Utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China.Brain and behavior · 2024Article
- Innovative Multivariable Model Combining MRI Radiomics and Plasma Indexes Predicts Alzheimer's Disease Conversion: Evidence from a 2-Cohort Longitudinal Study.Research (Washington, D.C.) · 2024Article
- The impact of education and occupation on cognitive impairment: a cross-sectional study in China.Frontiers in aging neuroscience · 2024Article
- A Stable and Scalable Digital Composite Neurocognitive Test for Early Dementia Screening Based on Machine Learning: Model Development and Validation Study.Journal of medical Internet research · 2023Article
- Risk factors for postoperative cognitive dysfunction in elderly patients undergoing surgery for oral malignancies.Perioperative medicine (London, England) · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMild cognitive impairment (MCI), defined as a transitional zone between normal cognition and dementia, requires a battery of formal neuropsychological tests administered by a trained rater for its diagnosis. The objective of this study was to develop a screening tool for MCI.
methodsOne hundred ninety seven cognitively normal controls (NC), one hundred sixteen patients with amnestic MCI -single domain (aMCI-sd), one hundred ninety five patients with amnestic MCI-multiple domain (aMCI-md), and two hundred twenty eight patients with mild Alzheimer's disease (AD) were evaluated by comprehensive neuropsychological tests and by the Memory and Executive Screening (MES).
resultsCorrelation analysis showed that the three indicators of the MES were significantly negatively related with age (P<0.05), yet not related with education (P>0.05). There was no ceiling or floor effect. Test completion averaged seven minutes (421.14±168.31 seconds). The receiver operating characteristics (ROC) analyses performed on the aMCI-sd group yielded 0.89 for the area under the curve (AUC) (95% CI, 0.85-0.92) for the MES-total score, with sensitivity of 0.795 and specificity of 0.828. There was 81% correct classification rate when the cut-off was set at less than 75. Meanwhile, the aMCI-md group yielded 0.95 for the AUC (95% CI, 0.93-0.97) for the MES-total score, with sensitivity of 0.87 and specificity of 0.91, and 90% correct classification rate when the cut-off was set at less than 72.
conclusionThe MES, minimally time-consuming, may be a valid and easily administered cognitive screening tool with high sensitivity and specificity for aMCI, with single or multiple domain impairment.
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