ArticleJournal of neurochemistry2012
Activation of immune responses to brain antigens after stroke.
Article in Journal of neurochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke.Current neurology and neuroscience reports · 2023Review
- Dynamic Process of Secondary Pulmonary Infection in Mice With Intracerebral Hemorrhage.Frontiers in immunology · 2021Article
- A longitudinal study of the post-stroke immune response and cognitive functioning: the StrokeCog study protocol.BMC neurology · 2020Article
- Antigen-Dependent T Cell Response to Neural Peptides After Human Ischemic Stroke.Frontiers in cellular neuroscience · 2020Article
- A year-long immune profile of the systemic response in acute stroke survivors.Brain : a journal of neurology · 2019Article
- Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy.Frontiers in molecular neuroscience · 2019Review
- Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury.Stroke · 2018Article
- Correction to: Neuroimmune Response in Ischemic Preconditioning.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Article
- Oxidative Stress in Hypoxic-Ischemic Encephalopathy: Molecular Mechanisms and Therapeutic Strategies.International journal of molecular sciences · 2016Review
- Neuroimmune Response in Ischemic Preconditioning.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Non-invasive tracking of CD4+ T cells with a paramagnetic and fluorescent nanoparticle in brain ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The use of microRNAs to modulate redox and immune response to stroke.Antioxidants & redox signaling · 2015Review
- Comprehensive immunophenotyping of cerebrospinal fluid cells in patients with neuroimmunological diseases.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Inflammatory responses in hypoxic ischemic encephalopathy.Acta pharmacologica Sinica · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically mediated suppression of the peripheral immune response. The teleological explanation for this immune dysfunction is that it serves to prevent autoimmune responses to brain antigens. We believe that the systemic immune response in patients who develop infection, however, thwarts this seemingly protective response and predisposes to central nervous system autoimmunity. These autoimmune responses may mediate, at least in part, the worse outcome associated with post-stroke infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.