Evidence map›Paper›PMID 23050554›Full record

ArticleBMC infectious diseases2012

A three-source capture-recapture estimate of the number of new HIV diagnoses in children in France from 2003-2006 with multiple imputation of a variable of heterogeneous catchability.

Vanina Héraud-Bousquet, Florence Lot, Maxime Esvan, Françoise Cazein, Corinne Laurent, Josiane Warszawski, Anne Gallay

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Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

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16citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  16. Number of HIV-infected cases in Iran: True or just an iceberg.Indian journal of sexually transmitted diseases and AIDS
    Article
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Vanina Héraud-BousquetInstitut de Veille Sanitaire, Département des maladies infectieuses, St Maurice, France. v.bousquet@invs.sante.fr
Florence Lot
Maxime Esvan
Françoise Cazein
Corinne Laurent
Josiane Warszawski
Anne Gallay

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNearly all HIV infections in children worldwide are acquired through mother-to-child transmission (MTCT) during pregnancy, labour, delivery or breastfeeding. The objective of our study was to estimate the number and rate of new HIV diagnoses in children less than 13 years of age in mainland France from 2003-2006.

methodsWe performed a capture-recapture analysis based on three sources of information: the mandatory HIV case reporting (DOVIH), the French Perinatal Cohort (ANRS-EPF) and a laboratory-based surveillance of HIV (LaboVIH). The missing values of a variable of heterogeneous catchability were estimated through multiple imputation. Log-linear modelling provided estimates of the number of new HIV infections in children, taking into account dependencies between sources and variables of heterogeneous catchability.

resultsThe three sources observed 216 new HIV diagnoses after record-linkage. The number of new HIV diagnoses in children was estimated at 387 (95%CI [271-503]) from 2003-2006, among whom 60% were born abroad. The estimated rate of new HIV diagnoses in children in mainland France was 9.1 per million in 2006 and was 38 times higher in children born abroad than in those born in France. The estimated completeness of the three sources combined was 55.8% (95% CI [42.9 - 79.7]) and varied according to the source; the completeness of DOVIH (28.4%) and ANRS-EPF (26.1%) were lower than that of LaboVIH (33.3%).

conclusionOur study provided, for the first time, an estimated annual rate of new HIV diagnoses in children under 13 years old in mainland France. A more systematic HIV screening of pregnant women that is repeated during pregnancy among women likely to engage in risky behaviour is needed to optimise the prevention of MTCT. HIV screening for children who migrate from countries with high HIV prevalence to France could be recommended to facilitate early diagnosis and treatment.

Indexed as

ChildChild, PreschoolFemaleFranceHIV InfectionsHumansIncidenceInfantInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancy

Identifiers

PMID23050554
PMCPMC3526568

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