Evidence map›Paper›PMID 23050076›Full record

ArticleInterface focus2011

Nucleic acid-based nanoengineering: novel structures for biomedical applications.

Hanying Li, Thomas H Labean, Kam W Leong

Abstract read
In one paragraph

Article in Interface focus, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Recent Progress of Magnetically Actuated DNA Micro/Nanorobots.Cyborg and bionic systems (Washington, D.C.) · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Comparative Incorporation of PNA into DNA Nanostructures.Molecules (Basel, Switzerland) · 2015
    Article
  13. Article
  14. Review
  15. Hepatic RNA Interference: Delivery by Synthetic Vectors.Drug delivery and translational research · 2014
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hanying LiDepartment of Biomedical Engineering , Duke University , 136 Hudson Hall, PO Box 90281, Durham, NC 27708 , USA.
Thomas H Labean
Kam W Leong

Funding

Oral Nonviral Gene Delivery for Hemophilla AR01HL089764 · NHLBI · DUKE UNIVERSITY · PI LEONG, KAM W · 2008 to 2011
$1.7M
NHLBI NIH HHS R01 HL089764
6 · The paper itself

Abstract

Nanoengineering exploits the interactions of materials at the nanometre scale to create functional nanostructures. It relies on the precise organization of nanomaterials to achieve unique functionality. There are no interactions more elegant than those governing nucleic acids via Watson-Crick base-pairing rules. The infinite combinations of DNA/RNA base pairs and their remarkable molecular recognition capability can give rise to interesting nanostructures that are only limited by our imagination. Over the past years, creative assembly of nucleic acids has fashioned a plethora of two-dimensional and three-dimensional nanostructures with precisely controlled size, shape and spatial functionalization. These nanostructures have been precisely patterned with molecules, proteins and gold nanoparticles for the observation of chemical reactions at the single molecule level, activation of enzymatic cascade and novel modality of photonic detection, respectively. Recently, they have also been engineered to encapsulate and release bioactive agents in a stimulus-responsive manner for therapeutic applications. The future of nucleic acid-based nanoengineering is bright and exciting. In this review, we will discuss the strategies to control the assembly of nucleic acids and highlight the recent efforts to build functional nucleic acid nanodevices for nanomedicine.

Indexed as

DNAdrug deliverynanomedicineorigamiself-assemblytemplated display

Identifiers

PMID23050076
PMCPMC3262286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.