Trial reportPloS one2012
Computational mapping identifies localized mechanisms for ablation of atrial fibrillation.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02997254 (COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation), which is not on this map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation
Who cites it
58 citing papers in PubMed, 92 citations in OpenAlex.
- RADAR: A Multicenter Food and Drug Administration Investigational Device Exemption Clinical Trial of Persistent Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2020Trial
- Direct or coincidental elimination of stable rotors or focal sources may explain successful atrial fibrillation ablation: on-treatment analysis of the CONFIRM trial (Conventional ablation for AF with or without focal impulse and rotor modulation).Journal of the American College of Cardiology · 2013Trial
- Spiral defect chaos with intermittency increases mean termination time.Physical review. E · 2025Article
- Persistent atrial fibrillation ablation: glimpsing the light ahead?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Spatially Conserved Spiral Wave Activity During Human Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2024Article
- [New mapping tools for catheter ablation of atrial fibrillation].Herzschrittmachertherapie & Elektrophysiologie · 2022Review
- The physics of heart rhythm disorders.Physics reports · 2022Article
- Convolutional Neural Networks for Mechanistic Driver Detection in Atrial Fibrillation.International journal of molecular sciences · 2022Article
- Future Directions for Mapping Atrial Fibrillation.Arrhythmia & electrophysiology review · 2022Review
- Intermittent trapping of spiral waves in a cardiac model.Physical review. E · 2022Article
- Epiphenomenal Re-Entry and Spurious Focal Activation Detection by Atrial Fibrillation Mapping Algorithms.JACC. Clinical electrophysiology · 2021Article
- Novel mapping techniques for rotor core detection using simulated intracardiac electrograms.Journal of cardiovascular electrophysiology · 2021Article
- Three dimensional reconstruction to visualize atrial fibrillation activation patterns on curved atrial geometry.PloS one · 2021Article
- Atrial Fibrillation Triggered by Premature Ventricular Complexes: An Under-Recognized Trigger.JACC. Case reports · 2020Article
- Linking Electrical Drivers With Atrial Cardiomyopathy for the Targeted Treatment of Atrial Fibrillation.Frontiers in physiology · 2020Review
- Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms.Frontiers in bioengineering and biotechnology · 2020Article
- Mapping and Ablation of Rotational and Focal Drivers in Atrial Fibrillation.Cardiac electrophysiology clinics · 2019Review
- Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes.Medical image analysis · 2019Article
- Chaotic tip trajectories of a single spiral wave in the presence of heterogeneities.Physical review. E · 2019Article
- Comparing phase and electrographic flow mapping for persistent atrial fibrillation.Pacing and clinical electrophysiology : PACE · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Atrial fibrillation (AF) is the most common heart rhythm disorder in the Western world and a common cause of hospitalization and death. Pharmacologic and non-pharmacologic therapies have met with limited success, in part due to an incomplete understanding of the underlying mechanisms for AF. AF is traditionally characterized by spatiotemporally disorganized electrical activation and, although initiating triggers for AF are described, it is unclear whether AF is sustained by spatially meandering continuous excitation (re-entrant waves), localized electrical sources within the atria, or some other mechanism. This has limited therapeutic options for this condition. Here we show that human AF is predominantly caused by a small number (1.8 ± 0.9) of localized re-entrant waves or repetitive focal beats, that remain stable with limited spatial migration over prolonged periods of time. Radiofrequency ablation that selectively targeted the sites of these sources was able to immediately terminate fibrillation and eliminate the arrhythmia with high success. Our results show that human AF, despite apparent spatiotemporal disorganization, is often perpetuated by a few spatially-constrained and temporally conserved sources whose targeted ablation can eliminate this complex rhythm disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.