ArticlePloS one2012
The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Characterization of velvet family proteins regulating fungal development and virulence in the peach shoot blight fungusVirulence · 2026Article
- Contribution of MylA in Conidiogenesis, Conidia Germination, and beta-Glucan Biosynthesis inJournal of microbiology and biotechnology · 2026Article
- ThemBio · 2026Article
- The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development.Life science alliance · 2026Article
- Light restores sporulation in Rhizopus microsporus cured of its endosymbionts, unveiling their role in fitness and virulence.The ISME journal · 2026Article
- Metabolic reprogramming landscape orchestrating chlamydospore formation inFrontiers in microbiology · 2026Article
- Functional dissection of velvet DNA-binding region inIMA fungus · 2026Article
- Article
- Members of Velvet Complex FpVeA and FpVelB Regulate Asexual Development, Fumonisin Biosynthesis and Virulence inFoods (Basel, Switzerland) · 2025Article
- Regulation ofToxins · 2025Article
- Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD inmBio · 2025Article
- The hyphae-specific CmSphere · 2025Article
- Article
- Role of the LAMMER kinase LkhA in fungal development and aflatoxin production in Aspergillus flavus.Journal of microbiology (Seoul, Korea) · 2025Article
- Identification of the ADH gene family in Trichosporon asahii and the role of TaADH_like in pathogenicity and fluconazole resistance.BMC genomics · 2025Article
- Characterization of Blue Light Receptors LreA and LreB inJournal of microbiology and biotechnology · 2025Article
- Essential Role of theMycobiology · 2025Article
- Set1/COMPASS regulates growth, pathogenicity, and patulin biosynthesis of Penicillium expansum via H3K4 methylation and the interaction with PeVelB.Journal of advanced research · 2024Article
- The MYB-like protein MylA contributes to conidiogenesis and conidial germination in Aspergillus nidulans.Communications biology · 2024Article
- Velvet Family Protein FpVelB Affects Virulence in Association with Secondary Metabolism inCells · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The multifunctional regulator VelB physically interacts with other velvet regulators and the resulting complexes govern development and secondary metabolism in the filamentous fungus Aspergillus nidulans. Here, we further characterize VelB's role in governing asexual development and conidiogenesis in A. nidulans. In asexual spore formation, velB deletion strains show reduced number of conidia, and decreased and delayed mRNA accumulation of the key asexual regulatory genes brlA, abaA, and vosA. Overexpression of velB induces a two-fold increase of asexual spore production compared to wild type. Furthermore, the velB deletion mutant exhibits increased conidial germination rates in the presence of glucose, and rapid germination of conidia in the absence of external carbon sources. In vivo immuno-pull-down analyses reveal that VelB primarily interacts with VosA in both asexual and sexual spores, and VelB and VosA play an inter-dependent role in spore viability, focal trehalose biogenesis and control of conidial germination. Genetic and in vitro studies reveal that AbaA positively regulates velB and vosA mRNA expression during sporogenesis, and directly binds to the promoters of velB and vosA. In summary, VelB acts as a positive regulator of asexual development and regulates spore maturation, focal trehalose biogenesis and germination by interacting with VosA in A. nidulans.
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