SynthesisPloS one2012
Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 8 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.Lipids in health and disease · 2019Pooled it
- Association of CD14-260 (-159) C/T and Alzheimer's disease: systematic review and trial sequential analyses.Journal of neural transmission (Vienna, Austria : 1996) · 2018Pooled it
- Association of XRCC3 gene rs861539 polymorphism with gastric cancer risk: evidence from a case-control study and a meta-analysis.International journal of clinical and experimental pathology · 2015Pooled it
- Characteristics of Japanese inflammatory bowel disease susceptibility loci.Journal of gastroenterology · 2014Pooled it
- Association of CD14 gene -159C/T polymorphism with allergic rhinitis risk: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Pooled it
- CD14 -159C/T polymorphism contributes to the susceptibility to tuberculosis: evidence from pooled 1,700 cases and 1,816 controls.Molecular biology reports · 2014Pooled it
- Contribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects.Scientific reports · 2014Pooled it
- Pooled it
- Two Types of Immune Checkpoint Inhibitor-related Pancreatitis.Internal medicine (Tokyo, Japan) · 2022Article
- Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease.Frontiers in pharmacology · 2022Review
- Association of CD14 rs2569190 G/A genetic polymorphism with the severity of enterovirus 71 infection in Chinese children.Virology · 2020Article
- Variations in CD14 Gene Are Associated With Autoimmune Thyroid Diseases in the Chinese Population.Frontiers in endocrinology · 2018Article
- Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir.PloS one · 2016Article
- Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout.Arthritis research & therapy · 2015Article
- The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals.Journal of translational medicine · 2015Article
- Lack of association between CD14-159 C/T polymorphism and acute pancreatitis: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Genetic association between CARD9 variants and inflammatory bowel disease was not replicated in a Chinese Han population.International journal of clinical and experimental pathology · 2015Article
- The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese population.BMC medical genetics · 2014Article
- Association between STAT3 gene polymorphisms and Crohn's disease susceptibility: a case-control study in a Chinese Han population.Diagnostic pathology · 2014Article
- Association of CD14/-260 polymorphism with gastric cancer risk in Highland Tibetans.World journal of gastroenterology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results. The aim of this study was to investigate the association between this polymorphism and IBD by conducting a meta-analysis. METHODOLOGY/PRINCIPAL
findingsSeventeen articles met the inclusion criteria, which included a total of 18 case-control studies, including 1900 ulcerative colitis (UC) cases, 2535 Crohn's disease (CD) cases, and 4004 controls. Data were analyzed using STATA software. Overall, association between C-260T polymorphism and increased UC risk was significant in allelic comparison (odds ratio [OR] =1.21, 95% confidence interval [CI]: 1.02-1.43; P=0.027), homozygote model (OR =1.44, 95% CI: 1.03-2.01; P=0.033), as well as dominant model (OR =1.36, 95% CI: 1.06-1.75; P=0.016). However, there was negative association between this polymorphism and CD risk across all genetic models. Subgroup analyses by ethnicity suggested the risk-conferring profiles of -260T allele and -260 TT genotype with UC in Asians, but not in Caucasians. There was a low probability of publication bias. CONCLUSIONS/SIGNIFICANCE: Expanding previous results of individual studies, our findings demonstrated that CD14 gene C-260T polymorphism might be a promising candidate marker in susceptibility to UC, especially in Asians.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.