ArticlePloS one2012
Structure and flexibility of the C-ring in the electromotor of rotary F(0)F(1)-ATPase of pea chloroplasts.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Carbon-to-ATP ratios across the kingdoms of life.iScience · 2026Article
- Chloroplast ATP synthase: From structure to engineering.The Plant cell · 2024Review
- ATP yield of plant respiration: potential, actual and unknown.Annals of botany · 2023Article
- The 3 × 120° rotary mechanism ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Correlation between the numbers of rotation steps in the ATPase and proton-conducting domains of F- and V-ATPases.Biophysical reviews · 2020Article
- Unusual features of the c-ring of FScientific reports · 2019Article
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Assembly of Spinach Chloroplast ATP Synthase Rotor Ring Protein-Lipid Complex.Frontiers in molecular biosciences · 2019Article
- Structure, mechanism, and regulation of the chloroplast ATP synthase.Science (New York, N.Y.) · 2018Article
- The Peripheral Stalk of Rotary ATPases.Frontiers in physiology · 2018Review
- The Phylogenetic Signature Underlying ATP Synthase c-Ring Compliance.Biophysical journal · 2015Article
- Fo-driven Rotation in the ATP Synthase Direction against the Force of F1 ATPase in the FoF1 ATP Synthase.The Journal of biological chemistry · 2015Article
- Integration of energy and electron transfer processes in the photosynthetic membrane of Rhodobacter sphaeroides.Biochimica et biophysica acta · 2014Article
- Crystallographic structure of the turbine C-ring from spinach chloroplast F-ATP synthase.Bioscience reports · 2014Article
- Residues in the polar loop of subunit c in Escherichia coli ATP synthase function in gating proton transport to the cytoplasm.The Journal of biological chemistry · 2014Article
- pH-dependent regulation of electron transport and ATP synthesis in chloroplasts.Photosynthesis research · 2013Review
- What makes you can also break you: mitochondrial permeability transition pore formation by the c subunit of the F(1)F(0) ATP-synthase?Frontiers in oncology · 2013Article
- Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A ring of 8-15 identical c-subunits is essential for ion-translocation by the rotary electromotor of the ubiquitous F(O)F(1)-ATPase. Here we present the crystal structure at 3.4Å resolution of the c-ring from chloroplasts of a higher plant (Pisum sativum), determined using a native preparation. The crystal structure was found to resemble that of an (ancestral) cyanobacterium. Using elastic network modeling to investigate the ring's eigen-modes, we found five dominant modes of motion that fell into three classes. They revealed the following deformations of the ring: (I) ellipsoidal, (II) opposite twisting of the luminal circular surface of the ring against the stromal surface, and (III) kinking of the hairpin-shaped monomers in the middle, resulting in bending/stretching of the ring. Extension of the elastic network analysis to rings of different c(n)-symmetry revealed the same classes of dominant modes as in P. sativum (c(14)). We suggest the following functional roles for these classes: The first and third classes of modes affect the interaction of the c-ring with its counterparts in F(O), namely subunits a and bb'. These modes are likely to be involved in ion-translocation and torque generation. The second class of deformation, along with deformations of subunits γ and ε might serve to elastically buffer the torque transmission between F(O) and F(1).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.