ArticleAdvances in hematology2012
Characterization of zebrafish von Willebrand factor reveals conservation of domain structure, multimerization, and intracellular storage.
Article in Advances in hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Animal models for thrombotic thrombocytopenic purpura: a narrative review.Annals of blood · 2023Article
- Fishing for answers to hemostatic and thrombotic disease: Genome editing in zebrafish.Research and practice in thrombosis and haemostasis · 2022Review
- Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular coevolution of coagulation factor VIII and von Willebrand factor.Blood advances · 2021Article
- Histone-induced thrombotic thrombocytopenic purpura inHaematologica · 2020Article
- Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasis.Blood advances · 2019Article
- Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow.Frontiers in microbiology · 2019Article
- Identification of extant vertebrateBlood · 2017Article
- Article
- Modeling Disorders of Blood Coagulation in the Zebrafish.Current pathobiology reports · 2015Article
- Article
- Corrigendum to "Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage".Advances in hematology · 2015Article
- Plasma fibronectin supports hemostasis and regulates thrombosis.The Journal of clinical investigation · 2014Article
- Zebrafish as a model system for the study of hemostasis and thrombosis.Current opinion in hematology · 2014Review
- Article
- Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia.PloS one · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
von Willebrand disease (VWD) is the most common inherited human bleeding disorder and is caused by quantitative or qualitative defects in von Willebrand factor (VWF). VWF is a secreted glycoprotein that circulates as large multimers. While reduced VWF is associated with bleeding, elevations in overall level or multimer size are implicated in thrombosis. The zebrafish is a powerful genetic model in which the hemostatic system is well conserved with mammals. The ability of this organism to generate thousands of offspring and its optical transparency make it unique and complementary to mammalian models of hemostasis. Previously, partial clones of zebrafish vwf have been identified, and some functional conservation has been demonstrated. In this paper we clone the complete zebrafish vwf cDNA and show that there is conservation of domain structure. Recombinant zebrafish Vwf forms large multimers and pseudo-Weibel-Palade bodies (WPBs) in cell culture. Larval expression is in the pharyngeal arches, yolk sac, and intestinal epithelium. These results provide a foundation for continued study of zebrafish Vwf that may further our understanding of the mechanisms of VWD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.