ArticleFrontiers in physiology2012
pCO(2) and pH regulation of cerebral blood flow.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis-A Systematic Review.Frontiers in neurology · 2022Pooled it
- The evidence for the physiological effects of lactate on the cerebral microcirculation: a systematic review.Journal of neurochemistry · 2019Pooled it
- Trial
- Therapeutic hypercapnia for prevention of secondary ischemia after severe subarachnoid hemorrhage: physiological responses to continuous hypercapnia.Scientific reports · 2021Trial
- Changes in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Robotic Surgery Improves Technical Performance and Enhances Prefrontal Activation During High Temporal Demand.Annals of biomedical engineering · 2018Trial
- Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial.Intensive care medicine · 2013Trial
- Carbon dioxide is a triple vasodilator.Cardiovascular research · 2026Article
- Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia.The Journal of physiology · 2026Review
- Rheopheresis, but Not Phlebotomy, Improves Cerebral Vascular Response to Hypercapnia and Neuronal Activation.Biomedicines · 2026Article
- PaCOFrontiers in medicine · 2026Review
- Prognostic Value of Ultrasonographic Optic Nerve Sheath Diameter in Patients with Sepsis in the Intensive Care Unit: A Prospective Observational Study.International journal of general medicine · 2026Article
- Cortical layer multi-parameter analysis of neurovascular impairments in AD/ADRD rodent model with in vivo optical imaging.Translational neurodegeneration · 2025Article
- First Breath Matters: Out-of-Hospital Mechanical Ventilation in Patients with Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Bridging brain and lung: optimizing mechanical ventilation in acute brain injury.Journal of anesthesia, analgesia and critical care · 2025Review
- Review
- Advancing Understanding of Cerebrovascular Hemodynamic Perturbations in Pediatric Cerebral Malaria Using a Modified Critical Closing Pressure Evaluation- A Prospective, Observational Study.Neurocritical care · 2025Observational
- Impact of early PaCOAnnals of intensive care · 2025Article
- Evaluation of intradialytic hypoxemia development in intensive care patients.BMC nephrology · 2025Observational
- Characterizing the protective vasodilatory effects of hypobaric hypoxia on the neurovascular coupling response.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CO(2) serves as one of the fundamental regulators of cerebral blood flow (CBF). It is widely considered that this regulation occurs through pCO(2)-driven changes in pH of the cerebral spinal fluid (CSF), with elevated and lowered pH causing direct relaxation and contraction of the smooth muscle, respectively. However, some findings also suggest that pCO(2) acts independently of and/or in conjunction with altered pH. This action may be due to a direct effect of CSF pCO(2) on the smooth muscle as well as on the endothelium, nerves, and astrocytes. Findings may also point to an action of arterial pCO(2) on the endothelium to regulate smooth muscle contractility. Thus, the effects of pH and pCO(2) may be influenced by the absence/presence of different cell types in the various experimental preparations. Results may also be influenced by experimental parameters including myogenic tone as well as solutions containing significantly altered HCO(3) (-) concentrations, i.e., solutions routinely employed to differentiate the effects of pH from pCO(2). In sum, it appears that pCO(2), independently and in conjunction with pH, may regulate CBF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.