ArticlePLoS biology2012
Independent regulation of basal neurotransmitter release efficacy by variable Ca²+ influx and bouton size at small central synapses.
Article in PLoS biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- CaCell reports · 2025Article
- Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone.Nature communications · 2022Article
- Correlative Live-Cell and Super-Resolution Imaging to Link Presynaptic Molecular Organisation With Function.Frontiers in synaptic neuroscience · 2022Article
- Impaired Pre-Motor Circuit Activity and Movement in a Drosophila Model of KCNMA1-Linked Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Fluorescence lifetime imaging reveals regulation of presynaptic CaJournal of neurochemistry · 2021Article
- Biodegradable Microcapsules Loaded with Nerve Growth Factor Enable Neurite Guidance and Synapse Formation.Pharmaceutics · 2020Article
- Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits.Science advances · 2020Article
- Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Preparation of dissociated mouse primary neuronal cultures from long-term cryopreserved brain tissue.Journal of neuroscience methods · 2020Article
- Posterior thalamic nucleus axon terminals have different structure and functional impact in the motor and somatosensory vibrissal cortices.Brain structure & function · 2019Article
- Multiplex imaging relates quantal glutamate release to presynaptic CaNature communications · 2019Article
- Optical Quantal Analysis Using CaFrontiers in synaptic neuroscience · 2019Article
- Imaging and Analysis of Presynaptic Calcium Influx in Cultured Neurons Using synGCaMP6f.Frontiers in synaptic neuroscience · 2019Article
- Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.Neuroscience · 2018Article
- Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS.Nature chemical biology · 2018Article
- Proteolytic maturation of αeLife · 2018Article
- Calcium dependence of spontaneous neurotransmitter release.Journal of neuroscience research · 2018Review
- Altered Synaptic Vesicle Release and CaFrontiers in molecular neuroscience · 2018Article
- Sodium Channel β2 Subunits Prevent Action Potential Propagation Failures at Axonal Branch Points.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The efficacy of action potential evoked neurotransmitter release varies widely even among synapses supplied by the same axon, and the number of release-ready vesicles at each synapse is a major determinant of this heterogeneity. Here we identify a second, equally important, mechanism for release heterogeneity at small hippocampal synapses, the inter-synaptic variation of the exocytosis probability of release-ready vesicles. Using concurrent measurements of vesicular pool sizes, vesicular exocytosis rates, and presynaptic Ca²⁺ dynamics, in the same small hippocampal boutons, we show that the average fusion probability of release-ready vesicles varies among synapses supplied by the same axon with the size of the spike-evoked Ca²⁺ concentration transient. We further show that synapses with a high vesicular release probability exhibit a lower Ca²⁺ cooperativity, arguing that this is a direct consequence of increased Ca²⁺ influx at the active zone. We conclude that variability of neurotransmitter release under basal conditions at small central synapses is accounted for not only by the number of release-ready vesicles, but also by their fusion probabilities, which are set independently of bouton size by variable spike-evoked presynaptic Ca²⁺ influx.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.