Evidence map›Paper›PMID 23049383›Full record

ArticleRevista brasileira de hematologia e hemoterapia2012

T-cell lymphomas in South america and europe.

Monica Bellei, Carlos Sergio Chiattone, Stefano Luminari, Emanuela Anna Pesce, Maria Elena Cabrera, Carmino Antonio de Souza, Raul Gabús, Lucia Zoppegno, Lucia Zoppegno, Jorge Milone and 12 more

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Revista brasileira de hematologia e hemoterapia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01142674 (Prospective Collection of Data in Pts With Peripheral T-Cell Lymphoma), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01142674 completednot on this map

Prospective Collection of Data in Pts With Peripheral T-Cell Lymphoma: PTCL,NOS;AITL; Extranodal NK/T-cell;Enteropathy-type; Hepatosplenic γ-δ; Subcutaneous Panniculitis-like; ALCL,Primary Systemic Type. By the Intl. T-Cell Lymphoma Project

TypeobservationalSponsorAssociazione Angela Serra per la ricerca sul cancroRan2006 to 2018Enrolled1,650ConditionsLymphoma, T-Cell, Peripheral
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. A genetic profiling guideline to support diagnosis and clinical management of lymphomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Guideline
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Impact ofBiomedicines · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. EntitiesHaematologica · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  17. Review
  18. Article
  19. What's new in peripheral T-cell lymphomas.Hematological oncology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 17 institutions in 11 countries.

Monica BelleiDepartment of Oncology, Hematology and Respiratory Diseases, L'Università di Modena e Reggio Emilia - UniMoRe, Modena, Italy.
Carlos Sergio Chiattone
Stefano Luminari
Emanuela Anna Pesce
Maria Elena Cabrera
Carmino Antonio de Souza
Raul Gabús
Lucia Zoppegno
Lucia Zoppegno
Jorge Milone
Astrid Pavlovsky
Joseph Michael Connors
Francine Mary Foss
Steven Michael Horwitz
Raymond Liang
Silvia Montoto
Stefano Aldo Pileri
Aaron Polliack
Julie Marie Vose
Pier Luigi Zinzani
Emanuele Zucca
Massimo Federico
University of Modena and Reggio Emilia · ITFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRFundación para la Investigación, Docencia y Prevención del Cáncer · ARHadassah Medical Center · ILHospital del Salvador · CLHospital Italiano de Buenos Aires · ARHospital Italiano La Plata · ARHospital Maciel · UYMemorial Sloan Kettering Cancer Center · USNebraska Medical Center · USQueen Mary University of London · GBUniversidade Estadual de Campinas (UNICAMP) · BRUniversità della Svizzera italiana · CHUniversity of Bologna · ITUniversity of British Columbia · CAUniversity of Hong Kong · HKYale Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral T-cell lymphomas are a group of rare neoplasms originating from clonal proliferation of mature post-thymic lymphocytes with different entities having specific biological characteristics and clinical features. As natural killer cells are closely related to T-cells, natural killer-cell lymphomas are also part of the group. The current World Health Organization classification recognizes four categories of T/natural killer-cell lymphomas with respect to their presentation: disseminated (leukemic), nodal, extranodal and cutaneous. Geographic variations in the distribution of these diseases are well documented: nodal subtypes are more frequent in Europe and North America, while extranodal forms, including natural killer-cell lymphomas, occur almost exclusively in Asia and South America. On the whole, T-cell lymphomas are more common in Asia than in western countries, usually affect adults, with a higher tendency in men, and, excluding a few subtypes, usually have an aggressive course and poor prognosis. Apart from anaplastic lymphoma kinase-positive anaplastic large cell lymphoma, that have a good outcome, other nodal and extranodal forms have a 5-year overall survival of about 30%. According to the principal prognostic indexes, the majority of patients are allocated to the unfavorable subset. In the past, the rarity of these diseases prevented progress in the understanding of their biology and improvements in the efficaciousness of therapy. Recently, international projects devoted to these diseases created networks promoting investigations on T-cell lymphomas. These projects are the basis of forthcoming cooperative, large scale trials to detail biologic characteristics of each sub-entity and to possibly individuate targets for new therapies.

Indexed as

EuropeHematologic neoplasmsKiller-cells, naturalLymphoma, T-Cell/classificationLymphoma, T-cell/epidemiologyLymphoma, T- cell/ pathologyPrognosisSouth America

Identifiers

PMID23049383
PMCPMC3459617
OpenAlexW2116438695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.