Evidence map›Paper›PMID 2304920›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1990

Contraction of neuronal branching volume: an anatomic correlate of Pavlovian conditioning.

D L Alkon, H Ikeno, J Dworkin, D L McPhie, J L Olds, I Lederhendler, L Matzel, B G Schreurs, A Kuzirian, C Collin

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 52 citations in OpenAlex.

  1. Binding of Gd(3+) to the neuronal signalling protein calexcitin identifies an exchangeable Ca(2+)-binding site.Acta crystallographica. Section F, Structural biology communications · 2016
    Article
  2. Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability.Proceedings of the National Academy of Sciences of the United States of America · 1996
    Article
  3. Operant conditioning of H-reflex changes synaptic terminals on primate motoneurons.Proceedings of the National Academy of Sciences of the United States of America · 1996
    Article
  4. Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  5. Characterization of a GTP-binding protein implicated in both memory storage and interorganelle vesicle transport.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  6. Transforming sensory experience into structural change.Proceedings of the National Academy of Sciences of the United States of America · 1993
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

D L AlkonLaboratory of Molecular and Cellular Neurobiology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
H Ikeno
J Dworkin
D L McPhie
J L Olds
I Lederhendler
L Matzel
B G Schreurs
A Kuzirian
C Collin
National Institute of Neurological Disorders and Stroke · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Associative memory of the mollusc Hermissenda crassicornis, previously correlated with changes of specific K+ currents, protein phosphorylation, and increased synthesis of mRNA and specific proteins, is here shown to be accompanied by macroscopic alteration in the structure of a single identified neuron, the medial type B photoreceptor cell. Four to five days after training, terminal arborizations of B cells iontophoretically injected with Ni2+ ions and then treated with rubeanic acid were measured with charge-coupled device (CCD)-digitized pseudocolor images of optical sections under "blind" conditions. Boundary volumes enclosing medial-type B-cell arborizations from classically conditioned animals were unequivocally reduced compared with volumes for naive animals or those trained with unpaired stimuli. Branch volume magnitude was correlated with input resistance of the medial type B-cell soma. Such associative learning-induced structural changes may share function with "synapse elimination" described in developmental contexts.

Indexed as

Conditioning, ClassicalAnimalsAssociation LearningAxonsMemoryMolluscaNervous SystemNervous System Physiological PhenomenaNeuronsPhotic Stimulation

Identifiers

PMID2304920
PMCPMC53525
OpenAlexW2152736243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.