ArticleMultidimensional systems and signal processing2012
Fisher information matrix for branching processes with application to electron-multiplying charge-coupled devices.
Article in Multidimensional systems and signal processing, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Article
- Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies.Communications biology · 2023Article
- LSTM-Autoencoder for Vibration Anomaly Detection in Vertical Carousel Storage and Retrieval System (VCSRS).Sensors (Basel, Switzerland) · 2023Article
- Tuning axial and lateral localization precision in 3D super-resolution microscopy with variable astigmatism.Optics letters · 2022Article
- Effect of Pixelation on the Parameter Estimation of Single Molecule Trajectories.IEEE transactions on computational imaging · 2021Article
- Information theoretic analysis of hyperspectral imaging systems with applications to fluorescence microscopy.Biomedical optics express · 2019Article
- A Theoretical High-Density Nanoscopy Study Leads to the Design of UNLOC, a Parameter-free Algorithm.Biophysical journal · 2018Article
- Three-Dimensional Localization of Single Molecules for Super-Resolution Imaging and Single-Particle Tracking.Chemical reviews · 2017Review
- Optimal Background Estimators in Single-Molecule FRET Microscopy.Biophysical journal · 2016Article
- Fisher information theory for parameter estimation in single molecule microscopy: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2016Article
- Deciphering the Structure and Function of Nuclear Pores Using Single-Molecule Fluorescence Approaches.Journal of molecular biology · 2016Review
- Simultaneous measurement of emission color and 3D position of single molecules.Optics express · 2016Article
- New results on the single molecule localization problem in two and three dimensions.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Investigation of the numerics of point spread function integration in single molecule localization.Optics express · 2015Article
- Determination of localization accuracy based on experimentally acquired image sets: applications to single molecule microscopy.Optics express · 2015Article
- An information-theoretic approach to designing the plane spacing for multifocal plane microscopy.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Quantitative Aspects of Single Molecule Microscopy.IEEE signal processing magazine · 2015Article
- Effect of time discretization of the imaging process on the accuracy of trajectory estimation in fluorescence microscopy.Optics express · 2014Article
- Extending single-molecule microscopy using optical Fourier processing.The journal of physical chemistry. B · 2014Article
- Designing the focal plane spacing for multifocal plane microscopy.Optics express · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The high quantum efficiency of the charge-coupled device (CCD) has rendered it the imaging technology of choice in diverse applications. However, under extremely low light conditions where few photons are detected from the imaged object, the CCD becomes unsuitable as its readout noise can easily overwhelm the weak signal. An intended solution to this problem is the electron-multiplying charge-coupled device (EMCCD), which stochastically amplifies the acquired signal to drown out the readout noise. Here, we develop the theory for calculating the Fisher information content of the amplified signal, which is modeled as the output of a branching process. Specifically, Fisher information expressions are obtained for a general and a geometric model of amplification, as well as for two approximations of the amplified signal. All expressions pertain to the important scenario of a Poisson-distributed initial signal, which is characteristic of physical processes such as photon detection. To facilitate the investigation of different data models, a "noise coefficient" is introduced which allows the analysis and comparison of Fisher information via a scalar quantity. We apply our results to the problem of estimating the location of a point source from its image, as observed through an optical microscope and detected by an EMCCD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.