ArticleHPB surgery : a world journal of hepatic, pancreatic and biliary surgery2012
The underlying mechanisms: how hypothyroidism affects the formation of common bile duct stones-a review.
Article in HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Interplay between lipid profiles, thyroid function, and gallstone disease: A clinical perspective.Journal of family medicine and primary care · 2025Article
- Hypothyroidism affects cholelithiasis causally: A two-sample bidirectional Mendelian randomization study.Journal of biomedical research · 2025Article
- Article
- Article
- The causal effects of thyroid function and lipids on cholelithiasis: A Mendelian randomization analysis.Frontiers in endocrinology · 2023Article
- Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice.International journal of molecular sciences · 2022Article
- Sex-Dependent Claudin-1 Expression in the Liver of Euthyroid and Hypothyroid Mice.European thyroid journal · 2015Article
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Authors and funding
3 authors.
Funding
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Abstract
For decades, one well-known risk factor for the development of gallbladder stones has been hypothyroidism. Recent studies have interestingly reported that the risk in particular for common bile duct (CBD) stones increases in clinical and subclinical hypothyroidism. There are multiple factors that may contribute to the formation and/or accumulation of CBD stones in hypothyroid patients, including decreased liver cholesterol metabolism, diminished bile secretion, and reduced sphincter of Oddi relaxation. This paper focuses on the mechanisms possibly underlying the association between hypothyroidism and CBD stones. The authors conclude that when treating patients with CBD stones or microlithiasis, clinicians should be aware of the possible hypothyroid background.
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Registered trials
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