SynthesisJournal of medical genetics2012
Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin.
Synthesis in Journal of medical genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.The Journal of clinical investigation · 2021Trial
- Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.The Lancet. Respiratory medicine · 2014Trial
- Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.American journal of respiratory and critical care medicine · 2014Trial
- Translational medicine for acute lung injury.Journal of translational medicine · 2024Review
- TM9SF1 offers utility as an efficient predictor of clinical severity and mortality among acute respiratory distress syndrome patients.Frontiers in immunology · 2024Article
- Review
- Acute respiratory distress syndrome heterogeneity and the septic ARDS subgroup.Frontiers in immunology · 2023Review
- Article
- The Epidemiology of Acute Respiratory Distress Syndrome Before and After Coronavirus Disease 2019.Critical care clinics · 2021Review
- Acute respiratory distress syndrome in a case of diabetic ketoacidosis requiring ECMO support.Endocrinology, diabetes & metabolism case reports · 2021Article
- A Data Report on the Curation and Development of a Database of Genes for Acute Respiratory Distress Syndrome.Frontiers in genetics · 2021Article
- A dissection of SARS‑CoV2 with clinical implications (Review).International journal of molecular medicine · 2020Review
- Lung protection in acute respiratory distress syndrome: what should we target?Current opinion in critical care · 2020Article
- Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality.Antioxidants & redox signaling · 2019Review
- Acute Respiratory Distress Syndrome Phenotypes.Seminars in respiratory and critical care medicine · 2019Review
- ACUTE RESPIRATORY DISTRESS SYNDROME IN A FOUR-YEAR-OLD BOY WITH DIABETIC KETOACIDOSIS - CASE REPORT.Acta clinica Croatica · 2018Article
- Fifty Years of Research in ARDS. Genomic Contributions and Opportunities.American journal of respiratory and critical care medicine · 2017Review
- Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome.The Lancet. Respiratory medicine · 2017Review
- Biomarkers for patients with trauma associated acute respiratory distress syndrome.Military Medical Research · 2017Review
- Interpretation of gene associations with risk of acute respiratory distress syndrome: P values, Bayes factors, positive predictive values, and need for replication.Critical care (London, England) · 2016Article
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundThe role of genetics in the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) from direct or indirect lung injury has not been specifically investigated. The aim of this study was to identify genetic variants contributing to ALI/ARDS from pulmonary or extrapulmonary causes.
methodsWe conducted a multistage genetic association study. We first performed a large-scale genotyping (50K ITMAT-Broad_CARe Chip) in 1717 critically ill Caucasian patients with either pulmonary or extrapulmonary injury, to identify single nucleotide polymorphisms (SNPs) associated with the development of ARDS from direct or indirect insults to the lung. Identified SNPs (p≤0.0005) were validated in two separated populations (Stage II), with trauma (Population I; n=765) and pneumonia/pulmonary sepsis (Population II; n=838), as causes for ALI/ARDS. Genetic variants replicating their association with trauma related-ALI in Stage II were validated in a second trauma-associated ALI population (n=224, Stage III).
resultsIn Stage I, non-overlapping SNPs were significantly associated with ARDS from direct/indirect lung injury, respectively. The association between rs1190286 (POPDC3) and reduced risk of ARDS from pulmonary injury was validated in Stage II (p<0.003). SNP rs324420 (FAAH) was consistently associated with increased risk of ARDS from extrapulmonary causes in two independent ALI-trauma populations (p<0.006, Stage II; p<0.05, Stage III). Meta-analysis confirmed these associations.
conclusionsDifferent genetic variants may influence ARDS susceptibility depending on direct versus indirect insults. Functional SNPs in POPDC3 and FAAH genes may be driving the association with direct and indirect ALI/ARDS, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.