Evidence map›Paper›PMID 23048018›Full record

Trial reportCerebral cortex (New York, N.Y. : 1991)2014

Shared and drug-specific effects of atomoxetine and methylphenidate on inhibitory brain dysfunction in medication-naive ADHD boys.

Ana Cubillo, Anna B Smith, Nadia Barrett, Vincent Giampietro, Michael J Brammer, Andrew Simmons, Katya Rubia

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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  6. Effects of fMRI neurofeedback of right inferior frontal cortex on inhibitory brain activation in children with ADHD.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Ana CubilloDepartment of Child Psychiatry.
Anna B Smith
Nadia Barrett
Vincent Giampietro
Michael J Brammer
Andrew Simmons
Katya Rubia
Cognitive Neuroimaging Lab · FR

Funding

Department of HealthMedical Research Council G0300155
6 · The paper itself

Abstract

The stimulant methylphenidate (MPX) and the nonstimulant atomoxetine (ATX) are the most commonly prescribed medications for attention deficit hyperactivity disorder (ADHD). However, no functional magnetic resonance imaging (fMRI) study has as yet investigated the effects of ATX on inhibitory or any other brain function in ADHD patients or compared its effects with those of MPX. A randomized, double-blind, placebo-controlled, crossover pharmacological design was used to compare the neurofunctional effects of single doses of MPX, ATX, and placebo during a stop task, combined with fMRI within 19 medication-naive ADHD boys, and their potential normalization effects relative to 29 age-matched healthy boys. Compared with controls, ADHD boys under placebo showed bilateral ventrolateral prefrontal, middle temporal, and cerebellar underactivation. Within patients, MPX relative to ATX and placebo significantly upregulated right ventrolateral prefrontal activation, which correlated with enhanced inhibitory capacity. Relative to controls, both drugs significantly normalized the left ventrolateral prefrontal underactivation observed under placebo, while MPX had a drug-specific effect of normalizing right ventrolateral prefrontal and cerebellar underactivation observed under both placebo and ATX. The findings show shared and drug-specific effects of MPX and ATX on performance and brain activation during inhibitory control in ADHD patients with superior upregulation and normalization effects of MPX.

Indexed as

Inhibition, PsychologicalAdolescentAdrenergic Uptake InhibitorsAnalysis of VarianceAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCatecholaminesCentral Nervous System StimulantsChildCross-Over StudiesData Interpretation, StatisticalDouble-Blind MethodHumansImage Processing, Computer-AssistedAdrenergic Uptake InhibitorsAtomoxetine HydrochlorideCatecholaminesCentral Nervous System StimulantsMethylphenidatePropylaminesatomoxetineattention deficit hyperactivity disorderfunctional magnetic resonance imagingmethylphenidatemotor response inhibitionstop task

Identifiers

PMID23048018
PMCPMC3862268
OpenAlexW2141333481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.