ArticleNucleic acids research2012
Distinct contributions of MSL complex subunits to the transcriptional enhancement responsible for dosage compensation in Drosophila.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Transcription initiation drives dosage compensation establishment and maintenance in maleScience advances · 2026Article
- Sex-specific variation in R-loop formation in Drosophila melanogaster.PLoS genetics · 2022Article
- Progressive dosage compensation during Drosophila embryogenesis is reflected by gene arrangement.EMBO reports · 2019Article
- Transcriptional modulation of entire chromosomes: dosage compensation.Journal of genetics · 2018Review
- An H4K16 histone acetyltransferase mediates decondensation of the X chromosome inEpigenetics & chromatin · 2016Article
- Dosage compensation in Drosophila.Cold Spring Harbor perspectives in biology · 2015Review
- Mechanisms of x chromosome dosage compensation.Journal of genomics · 2015Review
- Acoustic force spectroscopy.Nature methods · 2015Article
- X-marks the spot: X-chromosome identification during dosage compensation.Biochimica et biophysica acta · 2014Review
- Transcriptional control of a whole chromosome: emerging models for dosage compensation.Nature structural & molecular biology · 2014Review
- The C. elegans dosage compensation complex mediates interphase X chromosome compaction.Epigenetics & chromatin · 2014Article
- Expression, purification and proteomic analysis of recombinant histone H4 acetylated at lysine 16.Proteomics · 2013Article
- Histone H4 lysine 16 acetylated isoform synthesis opens new route to biophysical studies.Proteomics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The regulatory mechanism of dosage compensation is the paramount example of epigenetic regulation at the chromosomal level. In Drosophila, this mechanism, designed to compensate for the difference in the dosage of X-linked genes between the sexes, depends on the MSL complex that enhances the transcription of the single dose of these genes in males. We have investigated the function of various subunits of the complex in mediating dosage compensation. Our results confirm that the highly enriched specific acetylation of histone H4 at lysine 16 of compensated genes by the histone acetyl transferase subunit MOF induces a more disorganized state of their chromatin. We have determined that the association of the MSL complex reduces the level of negative supercoiling of the deoxyribonucleic acid of compensated genes, and we have defined the role that the other subunits of the complex play in this topological modification. Lastly, we have analyzed the potential contribution of ISWI-containing remodeling complexes to the architecture of compensated chromatin, and we suggest a role for this remodeling factor in dosage compensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.