ArticleJournal of applied toxicology : JAT2014
Modified hydra bioassay to evaluate the toxicity of multiple mycotoxins and predict the detoxification efficacy of a clay-based sorbent.
Article in Journal of applied toxicology : JAT, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Green-Engineered Barrier Creams with Montmorillonite-Chlorophyll Clays as Adsorbents for Benzene, Toluene, and Xylene.Separations · 2023Article
- Application of Edible Montmorillonite Clays for the Adsorption and Detoxification of Microcystin.ACS applied bio materials · 2021Article
- Article
- Tight sorption of arsenic, cadmium, mercury, and lead by edible activated carbon and acid-processed montmorillonite clay.Environmental science and pollution research international · 2021Article
- Decreased bioavailability of aminomethylphosphonic acid (AMPA) in genetically modified corn with activated carbon or calcium montmorillonite clay inclusion in soil.Journal of environmental sciences (China) · 2021Article
- Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls.Journal of fungi (Basel, Switzerland) · 2020Review
- Strong Adsorption of Dieldrin by Parent and Processed Montmorillonite Clays.Environmental toxicology and chemistry · 2020Article
- A high capacity bentonite clay for the sorption of aflatoxins.Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment · 2020Article
- Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals.Applied sciences (Basel, Switzerland) · 2019Article
- NovaSil clay for the protection of humans and animals from aflatoxins and other contaminants.Clays and clay minerals · 2019Article
- Development of broad-acting clays for the tight adsorption of benzo[a]pyrene and aldicarb.Applied clay science · 2019Article
- Development of enterosorbents that can be added to food and water to reduce toxin exposures during disasters.Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes · 2019Article
- Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins.Nanomaterials (Basel, Switzerland) · 2018Review
- Development of High Capacity Enterosorbents for Aflatoxin B1 and Other Hazardous Chemicals.Chemical research in toxicology · 2017Article
- Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co-exposures of aflatoxin and fumonisin.Journal of applied toxicology : JAT · 2014Article
- Review of the inhibition of biological activities of food-related selected toxins by natural compounds.Toxins · 2013Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Food shortages and a lack of food supply regulation in developing countries often leads to chronic exposure of vulnerable populations to hazardous mixtures of mycotoxins, including aflatoxin B(1) (AFB(1)) and fumonisin B(1) (FB(1)). A refined calcium montmorillonite clay [i.e. uniform particle size NovaSil (UPSN)] has been reported to tightly bind these toxins, thereby decreasing bioavailability in humans and animals. Hence, our objectives in the present study were to examine the ability of UPSN to bind mixtures of AFB(1) and FB(1) at gastrointestinally relevant pH in vitro, and to utilize a rapid in vivo bioassay to evaluate AFB(1) and FB(1) toxicity and UPSN efficacy. Isothermal sorption data indicated tight AFB(1) binding to UPSN surfaces at both pH 2.0 and 6.5, but substantially more FB(1) bound at pH 2.0 than 6.5. Site-specific competition occurred between the toxins when exposed to UPSN in combination. Importantly, treatment with UPSN resulted in significant protection to mycotoxin-exposed hydra maintained at pH 6.9-7.0. Hydra were exposed to FB(1), AFB(1) and FB(1) /AFB(1) combinations with and without UPSN. A toxic response over 92 h was rated based on morphology and mortality. Hydra assay results indicated a minimum effective concentration (MEC) of 20 µg ml(-1) for AFB(1), whereas the MEC for FB(1) was not reached. The MEC for co-exposure was 400 µg ml(-1) FB(1) + 10 µg ml(-1) AFB(1). This study demonstrates that UPSN sorbs both mycotoxins tightly at physiologically relevant pH levels, resulting in decreased bioavailability, and that a modified hydra bioassay can be used as an initial screen in vivo to predict efficacy of toxin-binding agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.