ArticleMedical care2012
Use of antipsychotics among older residents in VA nursing homes.
Article in Medical care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Determinants of Potentially Inappropriate Medication Use in Long-Term and Acute Care Settings: A Systematic Review.Journal of the American Medical Directors Association · 2017Pooled it
- Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes.PLoS medicine · 2013Pooled it
- Use of atypical antipsychotics in nursing homes and pharmaceutical marketing.Journal of the American Geriatrics Society · 2015Trial
- Initiation and Persistence of Antipsychotic Medications at Hospital Discharge Among Community-Dwelling Veterans With Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- Antihypertensive Deprescribing and Functional Status in VA Long-Term Care Residents With and Without Dementia.Journal of the American Geriatrics Society · 2025Article
- Factors Associated with Potentially Harmful Medication Prescribing in Nursing Homes: A Scoping Review.Journal of the American Medical Directors Association · 2022Article
- Antipsychotic initiation and new diagnoses excluded from quality-measure reporting among Veterans in community nursing homes contracted by the Veterans Health Administration in the United States.International journal of methods in psychiatric research · 2022Article
- A pharmacist-led pilot using a performance dashboard to improve psychotropic medication use in a skilled nursing facility.BMJ open quality · 2020Article
- Pimavanserin for the treatment of psychosis in Alzheimer's disease: A literature review.World journal of psychiatry · 2020Article
- Early and Accurate Identification of Parkinson Disease Among US Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019Article
- Prevalence and Variability in Medications Contributing to Polypharmacy in Long-Term Care Facilities.Drugs - real world outcomes · 2017Article
- Persistent use of psychotropic drugs in nursing home residents in Norway.BMC geriatrics · 2017Article
- Dual Health Care System Use and High-Risk Prescribing in Patients With Dementia: A National Cohort Study.Annals of internal medicine · 2017Observational
- Article
- Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses.Therapeutic advances in chronic disease · 2016Article
- Multi-psychotropic drug prescription and the association to neuropsychiatric symptoms in three Norwegian nursing home cohorts between 2004 and 2011.BMC geriatrics · 2016Article
- A retrospective, longitudinal study of factors associated with new antipsychotic medication use among recently admitted long-term care residents.BMC geriatrics · 2015Article
- Appropriateness of Psychopharmaco-logical Medication.Journal of the American Geriatrics Society · 2015Article
- Potentially suboptimal prescribing for older veteran nursing home patients with dementia.The Annals of pharmacotherapy · 2015Article
- Epidemiology of drug-disease interactions in older veteran nursing home residents.Journal of the American Geriatrics Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAntipsychotic medications are commonly prescribed to nursing home residents despite their well-established adverse event profiles. Because little is known about their use in Veterans Affairs (VA) nursing homes [ie, Community Living Centers (CLCs)], we assessed the prevalence and risk factors for antipsychotic use in older residents of VA CLCs.
methodsThis cross-sectional study included 3692 Veterans age 65 or older who were admitted between January 2004 and June 2005 to one of 133 VA CLCs and had a stay of ≥90 days. We used VA Pharmacy Benefits Management data to examine antipsychotic use and VA Medical SAS datasets and the Minimum Data Set to identify evidence-based indications for antipsychotic use (eg, schizophrenia, dementia with psychosis). We used multivariable logistic regression and generalized estimating equations to identify factors independently associated with antipsychotic receipt.
resultsOverall, 948/3692(25.7%) residents received an antipsychotic, of which 59.3% had an evidence-based indication for use. Residents with aggressive behavior [odds ratio (OR)=2.74, 95% confidence interval (CI), 2.04-3.67] and polypharmacy (9+ drugs; OR=1.84, 95% CI, 1.41-2.40) were more likely to receive antipsychotics, as were users of antidepressants (OR=1.37, 95% CI, 1.14-1.66), anxiolytic/hypnotics (OR=2.30, 95% CI, 1.64-3.23), or drugs for dementia (OR=1.52, 95% CI, 1.21-1.92). Those residing in Alzheimer/dementia special care units were also more likely to receive an antipsychotic (OR=1.66, 95% CI, 1.26-2.21). Veterans with dementia but no documented psychosis were as likely as those with an evidence-based indication to receive an antipsychotic (OR=1.10, 95% CI, 0.82-1.47).
conclusionsAntipsychotic use is common among VA nursing home residents aged 65 and older, including those without a documented evidence-based indication for use. Further quality improvement efforts are needed to reduce potentially inappropriate antipsychotic prescribing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.