ArticleNature communications2012
A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 149 papers.
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Who cites it
149 citing papers in PubMed, 462 citations in OpenAlex.
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- Combining multiple metabolic strategies for efficient production of longifolene inSynthetic and systems biotechnology · 2026Article
- Metabolic Engineering ofJournal of fungi (Basel, Switzerland) · 2026Article
- Establishment of a protoplast transformation method for the oleaginous yeast Rhodotorula toruloides.FEMS yeast research · 2026Article
- Green synthesis revolution: harnessing biological factories for sustainable insect pheromone production in agriculture.Frontiers in plant science · 2026Review
- Transcriptome-based analysis of oil accumulation pattern and key gene screening inFrontiers in plant science · 2026Article
- Lipid accumulation in nitrogen and phosphorus-limited yeast is caused by less growth-related dilution.Metabolic engineering · 2026Article
- Prospective Mapping of Transcriptional Changes Associated with Lipid and Carotenoid Production inBiology · 2025Article
- Chromosome-resolved genome assemblies of Rhodotorula toruloides reveal abnormal chromosomal evolution under artificial culture conditions.Scientific reports · 2025Article
- Acidification by nitrogen metabolism triggers extracellular biopolymer production in an oleaginous yeast.Applied and environmental microbiology · 2025Article
- Transcriptomics-based analysis of acetate and propionate transport and metabolism in Yarrowia lipolytica.Biotechnology for biofuels and bioproducts · 2025Article
- Nitrogen limitation causes a seismic shift in redox state and phosphorylation of proteins implicated in carbon flux and lipidome remodeling in Rhodotorula toruloides.Biotechnology for biofuels and bioproducts · 2025Article
- Microbial synthesis and extraction of value-added metabolites by Rhodotorula toruloides from waste stream: a sustainable approach.Microbial cell factories · 2025Review
- Heterologous expression of flavohemoglobin in Rhodotorula toruloides led to improved lipid production.Biotechnology letters · 2025Article
- Ethylene glycol metabolism in the oleaginous yeast Rhodotorula toruloides.Applied microbiology and biotechnology · 2025Article
- Molecular Regulation of Carotenoid Accumulation Enhanced by Oxidative Stress in the Food Industrial StrainFoods (Basel, Switzerland) · 2025Article
- Rhodosporidium toruloides-a new surrogate model to study rapamycin induced effects on human aging and cancer.Cellular and molecular life sciences : CMLS · 2025Article
- The role of ATP citrate lyase, phosphoketolase, and malic enzyme in oleaginous Rhodotorula toruloides.Applied microbiology and biotechnology · 2025Article
- Whole-genome based phylogeny and comparative genomics of Sporidiobolales and related taxa ofIMA fungus · 2025Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedZou, Hanfan [corrected to Zou, Hanfa]
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assembly of genome and transcriptome sequencing data reveals a genome of 20.2 Mb containing 8,171 protein-coding genes, the majority of which have multiple introns. Genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. Transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. The multi-omic map of R. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.