ReviewClinical pharmacology and therapeutics2012
The genetic and epigenetic basis of type 2 diabetes and obesity.
Review in Clinical pharmacology and therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02211651 (Maternal Adipose Tissue and Placental Dysfunction Programs the Fetus for Type 2 Diabetes), which is not on this map. Cited by 102 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Adipose Tissue and Placental Dysfunction Programs the Fetus for Type 2 Diabetes (PlacentA-DM)
Who cites it
102 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data.Social science & medicine (1982) · 2022Pooled it
- Educating for Equity Care Framework: Addressing social barriers of Indigenous patients with type 2 diabetes.Canadian family physician Medecin de famille canadien · 2019Pooled it
- The bright side and dark side of workplace social capital: opposing effects of gender on overweight among Japanese employees.PloS one · 2014Trial
- DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes.Clinical epigenetics · 2024Article
- Chia seeds ameliorate cardiac disease risk factors via alleviating oxidative stress and inflammation in rats fed high-fat diet.Scientific reports · 2024Article
- Gene-environment interactions and the case of body mass index and obesity: How much do they matter?PNAS nexus · 2023Article
- Nutrient regulation of the islet epigenome controls adaptive insulin secretion.The Journal of clinical investigation · 2023Article
- Prospective Advances in Genome Editing Investigation.Advances in experimental medicine and biology · 2023Article
- Excessive weight gain onset-age and risk of developing diabetes mellitus: a large, prospective Chinese cohort study.Frontiers in endocrinology · 2023Article
- Advancing Diabetes Prevention and Control in American Indians and Alaska Natives.Annual review of public health · 2022Review
- Interaction between a diabetes-related methylation site (TXNIP cg19693031) and variant (GLUT1 rs841853) on fasting blood glucose levels among non-diabetics.Journal of translational medicine · 2022Article
- Expression and methylation status ofGastroenterology and hepatology from bed to bench · 2022Article
- DNA Methylation and Type 2 Diabetes: Novel Biomarkers for Risk Assessment?International journal of molecular sciences · 2021Review
- New Pandemic: Obesity and Associated Nephropathy.Frontiers in medicine · 2021Review
- Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review.International journal of obesity (2005) · 2020Review
- Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.Epigenomics · 2020Article
- DNA methylation pattern changes following a short-term hypocaloric diet in women with obesity.European journal of clinical nutrition · 2020Article
- Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment.Biomolecules · 2020Review
- PKR inhibitors suppress endoplasmic reticulum stress and subdue glucolipotoxicity-mediated impairment of insulin secretion in pancreatic beta cells.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- Hypermethylation in Calca Promoter Inhibited ASC Osteogenic Differentiation in Rats with Type 2 Diabetic Mellitus.Stem cells international · 2020Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health problems. The evidence for familial aggregation of both T2D and obesity is substantial. To date, more than 150 genetic loci are associated with the development of monogenic, syndromic, or multifactorial forms of T2D or obesity. However, the proportion of overall trait variance explained by these associated loci is modest (~5-10% for T2D, ~2% for body mass index (BMI)). Some of the familial aggregation not attributable to known genetic variation, as well as many of the effects of environmental exposures, may reflect epigenetic processes. In this review, we discuss the evidence concerning the genetic contribution to individual risk of T2D and obesity, and explore the potential role of epigenetic mechanisms. We also explain how genetics, epigenetics, and environment are likely to interact to define the individual risk of disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.