ArticleBritish journal of cancer2012
Vascular endothelial growth factor signals through platelet-derived growth factor receptor β in meningiomas in vitro.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- A phase II trial of PTK787/ZK 222584 in recurrent or progressive radiation and surgery refractory meningiomas.Journal of neuro-oncology · 2014Trial
- Roles of PDGF/PDGFR signaling in various organs.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Review
- Meningioma growth beneath the outer membrane of a traumatic chronic subdural hematoma after burr-hole drainage: a case report and literature review.Frontiers in oncology · 2025Article
- Expression of somatostatin receptors in canine and feline meningioma.Veterinary medicine and science · 2024Article
- Lifestyle and metabolic factors affect risk for meningioma in women: a prospective population-based study (The Cohort of Norway).Frontiers in oncology · 2024Article
- UnderstandingCells · 2023Article
- The expression of platelet-derived growth factor and its receptor in canine and feline meningiomas.The Journal of veterinary medical science · 2023Article
- Extracellular Vesicles and Hypertension.Advances in experimental medicine and biology · 2023Article
- Lenvatinib improves anti-PD-1 therapeutic efficacy by promoting vascular normalization via the NRP-1-PDGFRβ complex in hepatocellular carcinoma.Frontiers in immunology · 2023Article
- Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells.Clinical and experimental nephrology · 2022Article
- Molecular neuropathology of brain-invasive meningiomas.Brain pathology (Zurich, Switzerland) · 2022Review
- Extracellular Vesicles in Essential Hypertension: Hidden Messengers.Current hypertension reports · 2020Review
- Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2020Review
- Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.Acta neuropathologica communications · 2019Article
- mRNA expression of tumor-associated genes in canine grade I meningiomas.The Journal of veterinary medical science · 2019Article
- Circulating Tumor Biomarkers in Meningiomas Reveal a Signature of Equilibrium Between Tumor Growth and Immune Modulation.Frontiers in oncology · 2019Article
- SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery.Acta neurochirurgica · 2018Article
- Sunitinib-induced morpho-functional changes and drug effectiveness in malignant solitary fibrous tumours.Oncotarget · 2016Article
- Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges.Archives of medical science : AMS · 2015Article
- An unusual complex karyotype in myopericytoma.Journal of orthopaedics · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVascular endothelial growth factor (VEGF)-mediated angiogenesis mediates tumour growth and metastasis. Meningiomas are primarily benign, slow-growing, highly vascularised tumours. Aside from VEGF, there is little data on the function of major angiogenic proteins in meningiomas.
methodsThe VEGFA, platelet-derived growth factor B (PDGFB), and their respective receptors - VEGF receptor 2 (KDR) and PDGF receptor β (PDGFRβ) - were quantified using real-time PCR and a TaqMan Protein Assay in meningiomas in vivo and in vitro. The effect of VEGFA and PDGFB on cell proliferation and the tyrosine phosphorylation of PDGFRβ were examined.
resultsMost meningiomas displayed no KDR protein expression but elevated PDGFRβ levels. Exogenous VEGFA stimulation significantly increased cell proliferation. The PDGFRβ inhibition before stimulation with VEGFA abolished the proliferative stimuli. The VEGFA induced concentration-dependent PDGFRβ tyrosine phosphorylation comparable to PDGFB-induced PDGFRβ tyrosine phosphorylation. The PDGFRβ inhibitors gambogic acid, sunitinib, and tandutinib equally impaired the migration of meningioma cells. In addition, gambogic acid suppressed the VEGFA-induced PDGFRβ tyrosine phosphorylation.
conclusionCollectively, our data suggest that VEGFA primarily regulates VEGF-mediated migration through PDGFRβ in meningiomas. The inhibitory effect of gambogic acid and tandutinib against meningioma growth in vitro suggests that selective PDGFRβ inhibitors, in combination with VEGF inhibitors, should be evaluated further as potential therapies for recurrent and malignant meningiomas.
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