ArticleJournal of perinatology : official journal of the California Perinatal Association2013
Discordance in neonatal risk factors and early childhood outcomes of very low birth weight (<1.5 kg) twins.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies.Development and psychopathology · 2021Pooled it
- Human milk and neurodevelopment in children with very low birth weight: a systematic review.Nutrition journal · 2014Pooled it
- Birth weight discordance, gene expression, and DNA methylation: A scoping review of epigenetic twin studies.PloS one · 2025Article
- Perinatal outcomes and growth discordance of triplet pregnancies based on chorionicity: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Exposure to heavy metals and trace elements among pregnant women with twins: levels and association with twin growth discordance.Frontiers in public health · 2024Article
- Comparison of neurodevelopmental outcomes between monochorionic and dichorionic twins with birth weight ≤ 1500 g in Japan: a register-based cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- The complex aetiology of cerebral palsy.Nature reviews. Neurology · 2018Review
- The Prenatal Environment in Twin Studies: A Review on Chorionicity.Behavior genetics · 2016Review
- Fault and blame, insults to the perinatal brain may be remote from time of birth.Clinics in perinatology · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo examine the rates of discordance in neonatal risk factors and neurodevelopmental outcomes within very low birth weight twin pairs and the factors associated with discordant outcomes. STUDY
designRates of neonatal risk factors and neurodevelopmental outcomes, and discordance in outcomes were examined for 88 very low birth weight twin pairs born between 1990 and 2005 and followed through 20 months' corrected age.
resultDiscordance rates ranged from 17 to 42% for neonatal risk factors and from 18 to 31% for neurodevelopmental outcomes. In regression analysis, affected co-twins were significantly more likely to have had an abnormal cerebral ultrasound than their unaffected co-twins in pairs discordant for cerebral palsy (odds ratio (OR): 13.00, 95% confidence interval (CI): 2.22 to 76.03)) and in pairs discordant for neurodevelopmental impairment (OR: 4.00, 95% CI: 1.13 to 14.18). Outcomes and discordance in outcomes were similar for monochorionic and dichorionic pairs.
conclusionDespite shared genetics and risk factors, twins may have discordant outcomes. Information on discordant neonatal and neurodevelopmental outcomes is important for counseling families of twins.
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Registered trials
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