ArticleTranslational psychiatry2012
Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior.
Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Gut microbiota regulates innate anxiety through neural activity of medial prefrontal cortex in male mice.Frontiers in neuroscience · 2025Article
- Advancing Post-Stroke Depression Research: Insights from Murine Models and Behavioral Analyses.Life (Basel, Switzerland) · 2024Review
- NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA.Molecular psychiatry · 2024Article
- Enriched Environment Attenuates Enhanced Trait Anxiety in Association with Normalization of Aberrant Neuro-Inflammatory Events.International journal of molecular sciences · 2022Article
- Anxiety and hippocampal neuronal activity: Relationship and potential mechanisms.Cognitive, affective & behavioral neuroscience · 2022Review
- Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action.Therapeutic advances in psychopharmacology · 2022Review
- Neuroinflammation Induction and Alteration of Hippocampal Neurogenesis in Mice Following Developmental Exposure to Gossypol.The international journal of neuropsychopharmacology · 2021Article
- Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women.Pain · 2021Article
- Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline.Translational psychiatry · 2020Article
- Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide.Scientific reports · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Epigenetic Mechanisms Within the Cingulate Cortex Regulate Innate Anxiety-Like Behavior.The international journal of neuropsychopharmacology · 2019Article
- Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli.Neural plasticity · 2018Article
- Modelling depression in animals: at the interface of reward and stress pathways.Psychopharmacology · 2017Review
- Hippocampal serotonin-2A receptor-immunoreactive neurons density increases after testosterone therapy in the gonadectomized male mice.Anatomy & cell biology · 2016Article
- Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis.Neural plasticity · 2016Review
- Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior.Annals of medicine · 2016Article
- The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis.Brain, behavior, and immunity · 2015Article
- Treatment-resistant depression: are animal models of depression fit for purpose?Psychopharmacology · 2015Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Adult neurogenesis has been implicated in affective disorders and the action of antidepressants (ADs) although the functional significance of this association is still unclear. The use of animal models closely mimicking human comorbid affective and anxiety disorders seen in the majority of patients should provide relevant novel information. Here, we used a unique genetic mouse model displaying higher trait anxiety (HAB) and comorbid depression-like behavior. We demonstrate that HABs have a lower rate of hippocampal neurogenesis and impaired functional integration of newly born neurons as compared with their normal anxiety/depression-like behavior (NAB) controls. In HABs, chronic treatment with the AD fluoxetine alleviated their higher depression-like behavior and protected them from relapse for 3 but not 7 weeks after discontinuation of the treatment without affecting neurogenesis. Similar to what has been observed in depressed patients, fluoxetine treatment induced anxiogenic-like effects during the early treatment phase in NABs along with a reduction in neurogenesis. On the other hand, treatment with AD drugs with a particularly strong anxiolytic component, namely the neurokinin-1-receptor-antagonist L-822 429 or tianeptine, increased the reduced rate of neurogenesis in HABs up to NAB levels. In addition, challenge-induced hypoactivation of dentate gyrus (DG) neurons in HABs was normalized by all three drugs. Overall, these data suggest that AD-like effects in a psychopathological mouse model are commonly associated with modulation of DG hypoactivity but not neurogenesis, suggesting normalization of hippocampal hypoactivity as a neurobiological marker indicating successful remission. Finally, rather than to higher depression-related behavior, neurogenesis seems to be linked to pathological anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.