ArticleJournal of endocrinological investigation2013
Altered bone status in unilateral testicular cancer survivors: Role of CYP2R1 and its luteinizing hormone-dependency.
Article in Journal of endocrinological investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Vitamin D Deficiency in Testicular Cancer Survivors: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Late-onset hypogonadism: beyond testosterone.Asian journal of andrologyTrial
- Vitamin D Status Determines Cardiometabolic Effects of Testosterone Replacement Therapy in Men with Late-Onset Hypogonadism.Nutrients · 2025Article
- Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours.Frontiers in oncology · 2023Article
- Risk of osteoporosis in testicular germ cell tumour survivors: A systematic review of the literature.BJUI compass · 2023Review
- Functional hypogonadism among patients with obesity, diabetes, and metabolic syndrome.International journal of impotence research · 2022Review
- Serum 25OHD3 of Obese Mice Is Affected by Liver Injury and Correlates with Testosterone Levels and Sperm Motility.Obesity facts · 2021Article
- Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues.JBMR plus · 2020Article
- Fertility Outcomes and Sperm-DNA Parameters in Metastatic Melanoma Survivors Receiving Vemurafenib or Dabrafenib Therapy: Case Report.Frontiers in oncology · 2020Article
- Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats.Journal of endocrinological investigation · 2019Article
- Hypogonadism and Sexual Dysfunction in Testicular Tumor Survivors: A Systematic Review.Frontiers in endocrinology · 2019Article
- Article
- Vitamin D, PCOS and androgens in men: a systematic review.Endocrine connections · 2018Review
- Increased risk of testis failure in testicular germ cell tumor survivors undergoing radiotherapy.Oncotarget · 2018Article
- The role of vitamin D in male fertility: A focus on the testis.Reviews in endocrine & metabolic disorders · 2017Review
- Vitamin D status among long-term survivors of testicular cancer.Oncotarget · 2017Article
- Role of vitamin D levels and vitamin D supplementation on bone mineral density in Klinefelter syndrome.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Vitamin D levels and bone mineral density: are LH levels involved in the pathogenesis of bone impairment in hypogonadal men?Journal of endocrinological investigation · 2014Observational
- CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Testicular function and bone metabolism--beyond testosterone.Nature reviews. Endocrinology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent data suggest a potential role of testis in vitamin D activation, where Leydig cells could represent key players in this process since they express the highest amount of CYP2R1, a key enzyme involved in vitamin D 25 hydroxylation.
aimTo evaluate bone status in unilateral orchiectomy and to assess in vivo and in vitro LH-dependency of Vitamin D 25 hydroxylation. SUBJECTS AND
methods125 normotestosteronemic patients with testicular cancer (TC), featured by unilateral orchiectomy and 41 age-matched healthy male controls were studied in the Center for Human Reproduction Pathology at the University of Padova. To evaluate LH-dependency of Vitamin D 25 hydroxylation in vitro, Leydig cell cultures were stimulated with hCG and assessed for CYP2R1 expression, whereas in vivo 10 hypogonadotropic hypogonadal (HH) patients were evaluated before and after treatment with gonadotropins for bone metabolism markers. Hormonal pattern and bone metabolism markers were measured in all subjects, whereas 105 patients and 41 controls underwent bone densitometry by DEXA.
resultsIn TC patients 25-hydroxyvitamin D levels were significantly lower compared to controls. Furthermore, 23.8% of patients with TC displayed low bone density (Z-score <-2 SD). None of the 41 control subjects showed any significant alteration of BMD. In vitro and in vivo studies revealed that CYP2R1 expression in Leydig cells appeared to be hCG dependent.
conclusionOur data show an association between TC and alteration of the bone status, despite unvaried androgen and estrogen levels, suggesting the evaluation of bone status and possible vitamin D deficiency in TC survivors.
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