ArticleHeredity2013
Herbicide resistance-endowing ACCase gene mutations in hexaploid wild oat (Avena fatua): insights into resistance evolution in a hexaploid species.
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 137 citations in OpenAlex.
- Asp-2078-Gly mutation confers ACCase-inhibiting herbicide resistance in Leptochloa chinensis (L.) Nees.Pest management science · 2026Article
- Subgenomic Distribution and Herbicide Cross-Resistance ofPlant direct · 2026Article
- Digitaria genome analyses indicate introgression may drive local adaptation and herbicide resistance.Nature communications · 2026Article
- Reference genome and population genomic analyses reveal insight into herbicide tolerance in Avena fatua L.Nature communications · 2025Article
- Herbicide resistance inFrontiers in plant science · 2025Article
- Repeated evolution of herbicide resistance inEvolutionary applications · 2023Article
- First Asp-2078-Gly Mutation Conferring Resistance to Different ACCase Inhibitors in aInternational journal of molecular sciences · 2022Article
- Inheritance of dicamba-resistance in allotetraploid Chenopodium album.Pest management science · 2022Article
- A naturally evolved mutation (Ser59Gly) in glutamine synthetase confers glufosinate resistance in plants.Journal of experimental botany · 2022Article
- Diverse mechanisms associated with cyhalofop-butyl resistance in Chinese sprangletop (Frontiers in plant science · 2022Article
- Herbicide resistance in grass weeds: Epigenetic regulation matters too.Frontiers in plant science · 2022Review
- Target-Site Mutations and Expression ofGenes · 2021Article
- An ABCC-type transporter endowing glyphosate resistance in plants.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- No fitness cost associated with Asn-2041-Ile mutation in winter wild oat (Avena ludoviciana) seed germination under various environmental conditions.Scientific reports · 2021Article
- Mechanisms of evolved herbicide resistance.The Journal of biological chemistry · 2020Review
- Molecular characteristics of the first case of haloxyfop-resistant Poa annua.Scientific reports · 2020Article
- Transgenic crops for the agricultural improvement in Pakistan: a perspective of environmental stresses and the current status of genetically modified crops.GM crops & food · 2020Review
- Resistance determination of the ACCase-inhibiting herbicide of clodinafop propargyl in Avena ludoviciana (Durieu), and study of their interaction using molecular docking and simulation.Molecular biology reports · 2019Article
- Fitness costs associated with acetyl-coenzyme A carboxylase mutations endowing herbicide resistance in American sloughgrass (Ecology and evolution · 2019Article
- Copy Number Variation in Acetolactate Synthase Genes of Thifensulfuron-Methyl ResistantFrontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many herbicide-resistant weed species are polyploids, but far too little about the evolution of resistance mutations in polyploids is understood. Hexaploid wild oat (Avena fatua) is a global crop weed and many populations have evolved herbicide resistance. We studied plastidic acetyl-coenzyme A carboxylase (ACCase)-inhibiting herbicide resistance in hexaploid wild oat and revealed that resistant individuals can express one, two or three different plastidic ACCase gene resistance mutations (Ile-1781-Leu, Asp-2078-Gly and Cys-2088-Arg). Using ACCase resistance mutations as molecular markers, combined with genetic, molecular and biochemical approaches, we found in individual resistant wild-oat plants that (1) up to three unlinked ACCase gene loci assort independently following Mendelian laws for disomic inheritance, (2) all three of these homoeologous ACCase genes were transcribed, with each able to carry its own mutation and (3) in a hexaploid background, each individual ACCase resistance mutation confers relatively low-level herbicide resistance, in contrast to high-level resistance conferred by the same mutations in unrelated diploid weed species of the Poaceae (grass) family. Low resistance conferred by individual ACCase resistance mutations is likely due to a dilution effect by susceptible ACCase expressed by homoeologs in hexaploid wild oat and/or differential expression of homoeologous ACCase gene copies. Thus, polyploidy in hexaploid wild oat may slow resistance evolution. Evidence of coexisting non-target-site resistance mechanisms among wild-oat populations was also revealed. In all, these results demonstrate that herbicide resistance and its evolution can be more complex in hexaploid wild oat than in unrelated diploid grass weeds. Our data provide a starting point for the daunting task of understanding resistance evolution in polyploids.
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