ArticleHeredity2013
Optimum design of family structure and allocation of resources in association mapping with lines from multiple crosses.
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Exploiting genetic diversity in two European maize landraces for improving Gibberella ear rot resistance using genomic tools.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Comparative Genomics: Insights on the Pathogenicity and Lifestyle ofInternational journal of molecular sciences · 2021Article
- The influence of QTL allelic diversity on QTL detection in multi-parent populations: a simulation study in sugar beet.BMC genomic data · 2021Article
- Increased Power To Dissect Adaptive Traits in Global Sorghum Diversity Using a Nested Association Mapping Population.Genetics · 2017Article
- Genome-wide mapping and prediction suggests presence of local epistasis in a vast elite winter wheat populations adapted to Central Europe.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Article
- Genetic control of protein content and sedimentation volume in European winter wheat cultivars.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Article
- Adult plant development in triticale (× triticosecale wittmack) is controlled by dynamic genetic patterns of regulation.G3 (Bethesda, Md.) · 2014Article
- Genetic dynamics underlying phenotypic development of biomass yield in triticale.BMC genomics · 2014Article
- Mapping dynamic QTL for plant height in triticale.BMC genetics · 2014Article
- Relatedness severely impacts accuracy of marker-assisted selection for disease resistance in hybrid wheat.Heredity · 2014Article
- Cross-validation in association mapping and its relevance for the estimation of QTL parameters of complex traits.Heredity · 2014Article
- Article
- Multiple-line cross QTL mapping for biomass yield and plant height in triticale (× Triticosecale Wittmack).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Combined linkage and linkage disequilibrium QTL mapping in multiple families of maize (Zea mays L.) line crosses highlights complementarities between models based on parental haplotype and single locus polymorphism.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Comparison of biometrical approaches for QTL detection in multiple segregating families.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Mapping QTL for agronomic traits in breeding populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Family mapping is based on multiple segregating families and is becoming increasingly popular because of its advantages over population mapping. Athough much progress has been made recently, the optimum design and allocation of resources for family mapping remains unclear. Here, we addressed these issues using a simulation study, resample model averaging and cross-validation approaches. Our results show that in family mapping, the predictive power and the accuracy of quatitative trait loci (QTL) detection depend greatly on the population size and phenotyping intensity. With small population sizes or few test environments, QTL results become unreliable and are hampered by a large bias in the estimation of the proportion of genotypic variance explained by the detected QTL. In addition, we observed that even though good results can be achieved with low marker densities, no plateau is reached with our full marker complement. This suggests that higher quality results could be achieved with greater marker densities or sequence data, which will be available in the near future for many species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.