ArticleJournal of psychiatry & neuroscience : JPN2013
Catechol-O-methyltransferase genotype modifies executive functioning and prefrontal functional connectivity in women with anorexia nervosa.
Article in Journal of psychiatry & neuroscience : JPN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Genetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review.Frontiers in psychology · 2024Pooled it
- Inclusion of the severe and enduring anorexia nervosa phenotype in genetics research: a scoping review.Journal of eating disorders · 2024Article
- Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023Review
- Belief Inflexibility and Cognitive Biases in Anorexia Nervosa-The Role of the Bias against Disconfirmatory Evidence and Its Clinical and Neuropsychological Correlates.Journal of clinical medicine · 2023Article
- The COMT Genetic Factor Regulates Chemotherapy-Related Prospective Memory Impairment in Survivors With HER2-/+ Breast Cancer.Frontiers in oncology · 2022Article
- Shift Toward Randomness in Brain Networks of Patients With Anorexia Nervosa: The Role of Malnutrition.Frontiers in neuroscience · 2021Article
- Interaction of Catechol-O-methyltransferase ValBrain and behavior · 2020Article
- Cortical Complexity in Anorexia Nervosa: A Fractal Dimension Analysis.Journal of clinical medicine · 2020Article
- Goal-directed vs. habitual instrumental behavior during reward processing in anorexia nervosa: an fMRI study.Scientific reports · 2019Article
- Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa.Molecular neurobiology · 2019Article
- Functional Connectivity Patterns and the Role of 5-HTTLPR Polymorphism on Network Architecture in Female Patients With Anorexia Nervosa.Frontiers in neuroscience · 2019Article
- Article
- Resting-state connectivity within and across neural circuits in anorexia nervosa.Brain and behavior · 2019Article
- Induced Pluripotent Stem Cells; New Tools for Investigating Molecular Mechanisms in Anorexia Nervosa.Frontiers in nutrition · 2019Review
- Reduced Resting-State Functional Connectivity in Current and Recovered Restrictive Anorexia Nervosa.Frontiers in psychiatry · 2017Article
- Partially restored resting-state functional connectivity in women recovered from anorexia nervosa.Journal of psychiatry & neuroscience : JPN · 2016Article
- Literature Review of Cognitive Neuroscience and Anorexia Nervosa.Current psychiatry reports · 2016Review
- Gyrification brain abnormalities as predictors of outcome in anorexia nervosa.Human brain mapping · 2015Article
- Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa.Frontiers in behavioral neuroscience · 2014Article
- Article
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Authors and funding
11 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnorexia nervosa is characterized by high levels of perseveration and inflexibility, which interfere with successful treatments. Dopamine (DA) signalling seems to play a key role in modulating the prefrontal cortex, since both DA deficiency and excess nega tively influence the efficiency of cognitive functions. The present study explores the effect of a functional polymorphism (Val158Met) in the catechol-O-methyltransferase (COMT) gene on the set-shifting abilities and prefrontal functional connectivity of patients with anorexia nervosa.
methodsAll participants performed the Wisconsin Card Sorting Task, and a subsample underwent resting-state functional magnetic resonance imaging.
resultsWe included 166 patients with DSM-IV lifetime anorexia nervosa and 140 healthy women in our study. Both underweight and weight-recovered patients with anorexia nervosa showed high levels of perseveration, but only in the underweight group did the Val158Met polymorphism affect cognitive performance, showing the U-shaped curve characteristic of increased DA signalling in the prefrontal cortex. Underweight patients with anorexia nervosa who are Met homozygotes had significantly higher levels of perseveration and increased prefrontal functional connectivity than underweight patients in the other genotype groups, indicating abnormal regional cortical processing. LIMITATIONS: Although our data show that grey matter reduction in starving patients with anorexia nervosa did not explain our findings, the cross-sectional design of the present study did not allow us to distinguish between the effects of starvation and those of low estrogen levels.
conclusionStarvation affects DA release in the prefrontal cortex of patients with anorexia nervosa with different effects on executive functioning and prefrontal functional connectivity according to the COMT genotype. This observation has several therapeutic implications that need to be addressed by future studies.
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