ArticleLipids in health and disease2012
Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice.
Article in Lipids in health and disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men.European journal of applied physiology · 2016Trial
- Exercise Rescues Obesogenic-Related Genes in the Female Hypothalamic Arcuate Nucleus: A Potential Role of miR-211 Modulation.International journal of molecular sciences · 2024Article
- Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2.Sports medicine and health science · 2023Article
- Resistance Exercise Training Improves Metabolic and Inflammatory Control in Adipose and Muscle Tissues in Mice Fed a High-Fat Diet.Nutrients · 2022Article
- Physical activity enhances fecal lactobacilli in rats chronically drinking sweetened cola beverage.Open life sciences · 2022Article
- Heat-killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high-fat diet in mice.Journal of applied microbiology · 2021Article
- Aerobic Exercise Ameliorates Cancer Cachexia-Induced Muscle Wasting through Adiponectin Signaling.International journal of molecular sciences · 2021Article
- Uric acid upregulates the adiponectin‑adiponectin receptor 1 pathway in renal proximal tubule epithelial cells.Molecular medicine reports · 2018Article
- Maternal intake of grape seed procyanidins during lactation induces insulin resistance and an adiponectin resistance-like phenotype in rat offspring.Scientific reports · 2017Article
- Exercise and dietary change ameliorate high fat diet induced obesity and insulin resistance via mTOR signaling pathway.Journal of exercise nutrition & biochemistry · 2016Article
- Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice.Nutrition & metabolism · 2016Article
- Voluntary physical activity prevents insulin resistance in a tissue specific manner.Physiological reports · 2015Article
- Vibration exercise decreases insulin resistance and modulates the insulin signaling pathway in a type 2 diabetic rat model.International journal of clinical and experimental medicine · 2015Article
- Skeletal muscle glucose metabolism and inflammation in the development of the metabolic syndrome.Reviews in endocrine & metabolic disorders · 2014Review
- Adiponectin is not required for exercise training-induced improvements in glucose and insulin tolerance in mice.Physiological reports · 2014Article
- The role of adiponectin signaling in metabolic syndrome and cancer.Reviews in endocrine & metabolic disorders · 2014Review
- Effects of interventions on adiponectin and adiponectin receptors.Journal of exercise rehabilitation · 2014Review
- Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models.Nutrition research and practice · 2014Article
- Resveratrol enhances exercise training responses in rats selectively bred for high running performance.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2013Article
- Immune and Inflammatory Signaling Pathways in Exercise and Obesity.American journal of lifestyle medicineArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to evaluate the protective effect of concurrent exercise in the degree of the insulin resistance in mice fed with a high-fat diet, and assess adiponectin receptors (ADIPOR1 and ADIPOR2) and endosomal adaptor protein APPL1 in different tissues.
methodsTwenty-four mice were randomized into four groups (n = 6): chow standard diet and sedentary (C); chow standard diet and simultaneous exercise training (C-T); fed on a high-fat diet and sedentary (DIO); and fed on a high-fat diet and simultaneous exercise training (DIO-T). Simultaneously to starting high-fat diet feeding, the mice were submitted to a swimming exercise training protocol (2 x 30 minutes, with 5 minutes of interval/day), five days per week, for twelve weeks (90 days). Animals were then euthanized 48 hours after the last exercise training session, and adipose, liver, and skeletal muscle tissue were extracted for an immunoblotting analysis.
resultsIR, IRs, and Akt phosphorylation decreased in the DIO group in the three analyzed tissues. In addition, the DIO group exhibited ADIPOR1 (skeletal muscle and adipose tissue), ADIPOR2 (liver), and APPL1 reduced when compared with the C group. However, it was reverted when exercise training was simultaneously performed. In parallel, ADIPOR1 and 2 and APPL1 protein levels significantly increase in exercised mice.
conclusionsOur findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.