Trial reportJournal of translational medicine2012
Application of a nanotechnology antimicrobial spray to prevent lower urinary tract infection: a multicenter urology trial.
Trial report in Journal of translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Efficacy and safety of preventing catheter-associated urinary tract infection by inhibiting catheter bacterial biofilm formation: a multicenter randomized controlled trial.Antimicrobial resistance and infection control · 2024Trial
- A preliminary report on the effectiveness of nanotechnology anti-microbial spray dressing in preventing Tenckhoff catheter exit-site infection.Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisTrial
- Analysis of the Pathogen Distribution and Antimicrobial Resistance after Plastic Surgery of the Urogenital System.Plastic and reconstructive surgery. Global open · 2024Article
- Penile prosthesis biofilm formation and emerging therapies against them.Translational andrology and urology · 2018Review
- Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances.Global challenges (Hoboken, NJ) · 2018Review
- The Status of Biofilms in Penile Implants.Microorganisms · 2017Review
- Clinical presentation, diagnosis and treatment of vulvovaginitis in girls: a current approach and review of the literature.World journal of pediatrics : WJP · 2017Review
- Significance of biofilm for the prosthetic surgeon.Current urology reports · 2014Review
Corrections and comments
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Authors and funding
37 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCatheter-associated urinary tract infection (CAUTI) is a common nosocomial device-associated infection. It is now recognized that the high infection rates were caused by the formation of biofilm on the surface of the catheters that decreases the susceptibility to antibiotics and results in anti-microbial resistance.In this study, we performed an in vitro test to explore the mechanism of biofilm formation and subsequently conducted a multi-center clinical trial to investigate the efficacy of CAUTI prevention with the application of JUC, a nanotechnology antimicrobial spray.
methodsSiliconized latex urinary catheters were cut into fragments and sterilized by autoclaving. The sterilized sample fragments were randomly divided into the therapy and control group, whereby they were sprayed with JUC and distilled water respectively and dried before use.The experimental standard strains of Escherichia coli (E. coli) were isolated from the urine samples of patients. At 16 hours and 7 days of incubation, the samples were extracted for confocal laser scanning microscopy.A total of 1,150 patients were accrued in the clinical study. Patients were randomized according to the order of surgical treatment. The odd array of patients was assigned as the therapy group (JUC), and the even array of patients was assigned as the control group (normal saline).
resultsAfter 16 hours of culture, bacterial biofilm formed on the surface of sample fragments from the control group. In the therapy group, no bacterial biofilm formation was observed on the sample fragments. No significant increase in bacterial colony count was observed in the therapy group after 7 days of incubation.On the 7th day of catheterization, urine samples were collected for bacterial culture before extubation. Significant difference was observed in the incidence of bacteriuria between the therapy group and control group (4.52% vs. 13.04%, p < 0.001).
conclusionsIn this study, the effectiveness of JUC in preventing CAUTI in a hospital setting was demonstrated in both in vitro and clinical studies.
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